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  Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity.

Vieira, A., Vergoni, B., Courtney, M., Druelle, N., Gjernes, E., Hadzic, B., et al. (2018). Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity. PLoS One, 13(8): e0201536. doi:10.1371/journal.pone.0201536.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-EA72-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BE45-A
Genre: Journal Article

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 Creators:
Vieira, A., Author
Vergoni, B., Author
Courtney, M., Author
Druelle, N., Author
Gjernes, E., Author
Hadzic, B., Author
Avolio, F., Author
Napolitano, T., Author
Sanz, S. N., Author
Mansouri, A.1, Author              
Collombat, P., Author
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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 Abstract: In the context of type 1 diabetes research and the development of insulin-producing β-cell replacement strategies, whether pancreatic ductal cells retain their developmental capability to adopt an endocrine cell identity remains debated, most likely due to the diversity of models employed to induce pancreatic regeneration. In this work, rather than injuring the pancreas, we developed a mouse model allowing the inducible misexpression of the proendocrine gene Neurog3 in ductal cells in vivo. These animals developed a progressive islet hypertrophy attributed to a proportional increase in all endocrine cell populations. Lineage tracing experiments indicated a continuous neo-generation of endocrine cells exhibiting a ductal ontogeny. Interestingly, the resulting supplementary β-like cells were found to be functional. Based on these findings, we suggest that ductal cells could represent a renewable source of new β-like cells and that strategies aiming at controlling the expression of Neurog3, or of its molecular targets/co-factors, may pave new avenues for the improved treatments of diabetes.

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Language(s): eng - English
 Dates: 2018-08-09
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0201536
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Title: PLoS One
Source Genre: Journal
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Pages: 22 Volume / Issue: 13 (8) Sequence Number: e0201536 Start / End Page: - Identifier: -