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  Cognitive effects of rhythmic auditory stimulation in Parkinson’s disease: A P300 study

Lei, J., Conradi, N., Abel, C., Frisch, S., Brodski-Guerniero, A., Hildner, M., et al. (2019). Cognitive effects of rhythmic auditory stimulation in Parkinson’s disease: A P300 study. Brain Research, 1716, 70-79. doi:10.1016/j.brainres.2018.05.016.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-EDE3-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D083-D
Genre: Journal Article

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 Creators:
Lei, Juan1, 2, 3, 4, Author
Conradi, Nadine1, 2, Author
Abel, Cornelius5, Author              
Frisch, Stefan2, 6, Author
Brodski-Guerniero, Alla7, Author
Hildner, Marcel2, Author
Kell, Christian A.2, 3, Author
Kaiser, Jochen1, Author
Schmidt-Kassow, Maren1, Author
Affiliations:
1Institute of Medical Psychology, Goethe University, 60528 Frankfurt am Main, Germany, ou_persistent22              
2Department of Neurology, Goethe University Frankfurt , 60598 Frankfurt am Main, Germany, ou_persistent22              
3Brain Imaging Center, Goethe University Frankfurt, 60598 Frankfurt am Main, Germany, ou_persistent22              
4Institute for Cell Biology and Neuroscience, Goethe University , 60438 Frankfurt am Main, Germany, ou_persistent22              
5Scientific Services, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421698              
6Institute of Psychology, Goethe University , 60323 Frankfurt am Main, Germany, ou_persistent22              
7MEG Unit, Brain Imaging Center, Goethe University , 60598 Frankfurt am Main, Germany, ou_persistent22              

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Free keywords: Temporal predictability ; Auditory-motor synchronization ; ERP; Neurodegenerative disease
 Abstract: Rhythmic auditory stimulation (RAS) may compensate dysfunctions of the basal ganglia (BG), involved with intrinsic evaluation of temporal intervals and action initiation or continuation. In the cognitive domain, RAS containing periodically presented tones facilitates young healthy participants’ attention allocation to anticipated time points, indicated by better performance and larger P300 amplitudes to periodic compared to random stimuli. Additionally, active auditory-motor synchronization (AMS) leads to a more precise temporal encoding of stimuli via embodied timing encoding than stimulus presentation adapted to the participants’ actual movements. Here we investigated the effect of RAS and AMS in Parkinson’s disease (PD). 23 PD patients and 23 healthy age-matched controls underwent an auditory oddball task. We manipulated the timing (periodic/random/adaptive) and setting (pedaling/sitting still) of stimulation. While patients elicited a general timing effect, i.e., larger P300 amplitudes for periodic versus random tones for both, sitting and pedaling conditions, controls showed a timing effect only for the sitting but not for the pedaling condition. However, a correlation between P300 amplitudes and motor variability in the periodic pedaling condition was obtained in control participants only. We conclude that RAS facilitates attentional processing of temporally predictable external events in PD patients as well as healthy controls, but embodied timing encoding via body movement does not affect stimulus processing due to BG impairment in patients. Moreover, even with intact embodied timing encoding, such as healthy elderly, the effect of AMS depends on the degree of movement synchronization performance, which is very low in the current study.

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Language(s): eng - English
 Dates: 2018-04-122017-07-262018-05-152018-05-162019-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.brainres.2018.05.016
 Degree: -

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Title: Brain Research
  Other : Brain Res.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1716 Sequence Number: - Start / End Page: 70 - 79 Identifier: ISSN: 0006-8993
CoNE: /journals/resource/954926250616