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  Feedforward mechanisms of excitatory and inhibitory cortical receptive fields.

Bruno, R. M., & Simons, D. J. (2002). Feedforward mechanisms of excitatory and inhibitory cortical receptive fields. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 22(24), 10966-10975. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12486192.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-EE5E-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-EE5F-A
Genre: Journal Article

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JNeurosci_22_2002_10966.pdf (Any fulltext), 620KB
 
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Bruno, Randy M.1, Author              
Simons, Daniel J., Author
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: thalamocortical; cortical circuitry; whisker; barrel; barreloid; ventroposterior medial nucleus; thalamus; cross correlation
 Abstract: Excitatory and inhibitory cortical layer IV neurons have distinctive response properties. Thalamocortical connectivity that may underlie differences was examined using cross-correlation analyses of pairs of thalamic and cortical neurons in the rat whisker/barrel system. Cortical layer IV cells discharging fast spikes, presumed inhibitory neurons, were distinguished from regular-spike units, presumed excitatory neurons, by the extracellular waveform shape. Regular-spike neurons fired less robustly and had smaller receptive fields (RFs) and greater directional tuning than fast-spike cells. Presumed excitatory neurons were less likely to receive thalamocortical connections, and their connections were, on average, weaker. RF properties of thalamic inputs to both cell types were equivalent, except that the most highly responsive thalamic cells contacted only fast-spike neurons. In contrast, the size and directional tuning of cortical RFs were related to the number of detectable thalamocortical inputs. Connected thalamocortical pairs were likely to have matching RF characteristics. The smaller, more directionally selective RFs of excitatory neurons may be a consequence of their weaker net thalamic drive, their more nonlinear firing characteristics and pervasive feedforward inhibition provided by strongly driven, broadly tuned inhibitory neurons.

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Language(s): eng - English
 Dates: 2002-07-122002-10-012002-12-15
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 22 (24) Sequence Number: - Start / End Page: 10966 - 10975 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1