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  Immunological tolerance to LCMV antigens differently affects control of acute and chronic virus infection in mice

Woopen, C., Straub, T., Schweier, O., Aichele, U., Düker, K., Boehm, T., et al. (2018). Immunological tolerance to LCMV antigens differently affects control of acute and chronic virus infection in mice. European Journal of Immunology, 48, 120-127. doi:10.1002/eji.201747156.

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Woopen, Christina1, Author
Straub, Tobias1, Author
Schweier, Oliver1, Author
Aichele, Ulrike1, Author
Düker, Katharina1, Author
Boehm, Thomas2, Author           
Pircher, Hanspeter1, Author
Affiliations:
1Institute for Immunology, University of Freiburg, Freiburg, Germany, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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Free keywords: Epitopes, Immunodominance, LCMV, T cells, Tolerance
 Abstract: Cytotoxic T lymphocytes (CTLs) play a key role in the control of lymphocytic horiomeningitis virus (LCMV) infection. In C57BL/6 mice (H‐2b), the CTL response is mainly directed against epitopes from the LCMV glycoprotein (GP) and the nucleoprotein (NP) which represent the two major viral proteins. The role of GP‐ versus NP‐derived epitopes for viral clearance was examined using transgenic (tg) mice ubiquitously expressing LCMV GP and NP, respectively. These mice lack GP‐ or NP‐specific CTLs and show decreased levels of GP‐ or NP‐specific antibodies as a result of tolerance induction. During acute LCMV infection, CTLs specific for GP‐ and NP‐derived epitopes are generated with similar frequencies. Nonetheless, we found that lack of GP‐ but not of NP‐specific CTLs abolished control of acute LCMV infection. In contrast, after high‐dose or chronic LCMV infection, virus elimination was delayed to a similar extent in GP‐ and NP‐tg mice. Thus, immunological tolerance to LCMV antigens differently affects virus clearance in acute and chronic infection settings. In addition, our data reveal that immunodominance of H‐2b‐restricted LCMV‐specific CTL epitopes and their antiviral activity do not strictly correlate.

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Language(s): eng - English
 Dates: 2018-08-11
 Publication Status: Published online
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1002/eji.201747156
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Title: European Journal of Immunology
  Other : Eur. J. Immunol.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 48 Sequence Number: - Start / End Page: 120 - 127 Identifier: ISSN: 0014-2980
CoNE: https://pure.mpg.de/cone/journals/resource/954925398487