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  Myosin II from rabbit skeletal muscle and Dictyostelium discoideum and its interaction with F-actin studied by (1)H NMR spectroscopy

Kany, H., Wolf, J., & Kalbitzer, H. R. (2002). Myosin II from rabbit skeletal muscle and Dictyostelium discoideum and its interaction with F-actin studied by (1)H NMR spectroscopy. FEBS Letters, 521(1), 121-126. doi:10.1016/S0014-5793(02)02855-7.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-EF78-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-EF79-B
Genre: Journal Article

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FEBSLett_521_2002_121.pdf (Any fulltext), 130KB
 
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 Creators:
Kany, Harry, Author
Wolf, Jones, Author
Kalbitzer, Hans Robert1, Author              
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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Free keywords: Nuclear magnetic resonance; Actin; Myosin
 Abstract: Mg-F-actin occurs in two conformational states, I and M, where the N-terminal amino acids are either immobile or highly mobile. In the rigor or ADP complex of rabbit myosin S1 with Mg-F-actin the N-terminal acetyl group of actin stays in its highly mobile state. The same is true for the complexes with the myosin motor domain from Dictyostelium discoideum. This excludes a direct strong interaction of the N-terminal amino acids with myosin in the rigor state as suggested. An interaction of the N-terminus of F-actin with myosin is also not promoted by occupying its low-affinity binding site(s) with divalent ions. The N-terminal high-mobility region may be part of a structural system which has evolved for releasing inadequate stress applied to the actin filaments.

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Language(s): eng - English
 Dates: 2002-04-242002-05-132002-05-272002-06-19
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 521 (1) Sequence Number: - Start / End Page: 121 - 126 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501