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  Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition

Benali, A., Trippe, J., Weiler, E., Mix, A., Petrasch-Parwez, E., Girzalsky, W., et al. (2011). Theta-Burst Transcranial Magnetic Stimulation Alters Cortical Inhibition. The Journal of Neuroscience, 31(4), 1193-1203. doi:10.1523/JNEUROSCI.1379-10.2011.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F024-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-F026-5
Genre: Journal Article

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 Creators:
Benali, A, Author
Trippe, J, Author
Weiler, E1, Author              
Mix, A, Author
Petrasch-Parwez, E, Author
Girzalsky, W, Author
Eysel, UT, Author
Erdmann, R, Author
Funke, K, Author
Affiliations:
1Ruhr-University Bochum, ou_persistent22              

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 Abstract: Human cortical excitability can be modified by repetitive transcranial magnetic stimulation (rTMS), but the cellular mechanisms are largely unknown. Here, we show that the pattern of delivery of theta-burst stimulation (TBS) (continuous versus intermittent) differently modifies electric activity and protein expression in the rat neocortex. Intermittent TBS (iTBS), but not continuous TBS (cTBS), enhanced spontaneous neuronal firing and EEG gamma band power. Sensory evoked cortical inhibition increased only after iTBS, although both TBS protocols increased the first sensory response arising from the resting cortical state. Changes in the cortical expression of the calcium-binding proteins parvalbumin (PV) and calbindin D-28k (CB) indicate that changes in spontaneous and evoked cortical activity following rTMS are in part related to altered activity of inhibitory systems. By reducing PV expression in the fast-spiking interneurons, iTBS primarily affected the inhibitory control of pyramidal cell output activity, while cTBS, by reducing CB expression, more likely affected the dendritic integration of synaptic inputs controlled by other classes of inhibitory interneurons. Calretinin, the third major calcium-binding protein expressed by another class of interneurons was not affected at all. We conclude that different patterns of TBS modulate the activity of inhibitory cell classes differently, probably depending on the synaptic connectivity and the preferred discharge pattern of these inhibitory neurons.

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 Dates: 2011-01
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1523/JNEUROSCI.1379-10.2011
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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 31 (4) Sequence Number: - Start / End Page: 1193 - 1203 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1