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  Age-dependent effects of brain stimulation on network centrality

Antonenko, D., Nierhaus, T., Meinzer, M., Prehn, K., Thielscher, A., Ittermann, B., et al. (2018). Age-dependent effects of brain stimulation on network centrality. NeuroImage, 176, 71-82. doi:10.1016/j.neuroimage.2018.04.038.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F6A7-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9A8E-0
Genre: Journal Article

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 Creators:
Antonenko, Daria1, 2, Author
Nierhaus, Till3, 4, Author              
Meinzer, Marcus5, Author
Prehn, Kristin1, Author
Thielscher, Axel6, 7, Author
Ittermann, Bernd8, Author
Flöel, Agnes1, 2, Author
Affiliations:
1Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22              
5Centre for Clinical Research, University of Queensland, Brisbane, Australia, ou_persistent22              
6Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
7Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark, ou_persistent22              
8Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, ou_persistent22              

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Free keywords: Aging; Eigenvector centrality mapping; Graph analysis; Resting-state functional connectivity; Transcranial direct current stimulation
 Abstract: Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate age-associated differential neural tDCS effects. Three “online” tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults. Active stimulation targeted the left sensorimotor network (active electrode over left sensorimotor cortex with right supraorbital reference electrode). A graph-based rs-fMRI data analysis approach (eigenvector centrality mapping) and complementary seed-based analyses characterized neural tDCS effects. An interaction between anodal tDCS and age group was observed. Specifically, centrality in bilateral paracentral and posterior regions (precuneus, superior parietal cortex) was increased in young, but decreased in older adults. Seed-based analyses revealed that these opposing patterns of tDCS-induced centrality modulation originated from differential effects of tDCS on functional coupling of the stimulated left paracentral lobule. Cathodal tDCS did not show significant effects. Our study provides first evidence for differential tDCS effects on neural network organization in young and older adults. Anodal stimulation mainly affected coupling of sensorimotor with ventromedial prefrontal areas in young and decoupling with posteromedial areas in older adults.

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Language(s): eng - English
 Dates: 2018-04-132017-11-222018-04-172018-04-182018-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.04.038
PMID: 29679735
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : 01GQ1424A
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 176 Sequence Number: - Start / End Page: 71 - 82 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166