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  Harmonic brain modes: A unifying framework for linking space and time in brain dynamics

Atasoy, S., Deco, G., Kringelbach, M. L., & Pearson, J. (2018). Harmonic brain modes: A unifying framework for linking space and time in brain dynamics. The Neuroscientist, 24(3), 277-293. doi:10.1177/1073858417728032.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F6E6-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-969A-6
Genre: Journal Article

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 Creators:
Atasoy, Selen 1, Author
Deco, Gustavo1, 2, 3, 4, Author              
Kringelbach, Morten L. 5, 6, Author
Pearson, Joel 7, Author
Affiliations:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Center for Music in the Brain, Aarhus University, Danmark, ou_persistent22              
7School of Psychology, University of New South Wales, Sydney, Australia, ou_persistent22              

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Free keywords: Resting state networks; Neural oscillations; Brain dynamics; Connectome harmonics; Sleep; Anesthesia; Psychedelics; Consciousness; Unifying framework
 Abstract: A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at “rest.” Here, we introduce the concept of harmonic brain modes—fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states (wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.

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Language(s): eng - English
 Dates: 2017-09-012018-06-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1177/1073858417728032
PMID: 28863720
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : BP-B 00270
Funding program : Programa Beatriu de Pinos 2014
Funding organization : Generalitat de Catalunya
Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7 (FP)
Funding organization : European Commission (EC)
Project name : -
Grant ID : GNT1046198 ; GNT1085404
Funding program : -
Funding organization : National Health and Medical Research Council (NHMRC)
Project name : -
Grant ID : DP140101560 ; DP160103299
Funding program : ARC Discovery Projects
Funding organization : National Health and Medical Research Council (NHMRC)
Project name : -
Grant ID : GNT1049596
Funding program : NHMRC Career Development Fellowship
Funding organization : National Health and Medical Research Council (NHMRC)

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Title: The Neuroscientist
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Thousand Oaks, Calif. : Sage Publications, Inc.
Pages: - Volume / Issue: 24 (3) Sequence Number: - Start / End Page: 277 - 293 Identifier: ISSN: 1073-8584
CoNE: https://pure.mpg.de/cone/journals/resource/954928616245_1