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  Mild cognitive impairment disrupts attention network connectivity in Parkinson's disease: A combined multimodal MRI and meta-analytical study

Bezdicek, O., Ballarini, T., Růžička, F., Roth, J., Mueller, K., Jech, R., et al. (2018). Mild cognitive impairment disrupts attention network connectivity in Parkinson's disease: A combined multimodal MRI and meta-analytical study. Neuropsychologia, 112, 105-115. doi:10.1016/j.neuropsychologia.2018.03.011.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F6E1-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A3A9-6
Genre: Journal Article

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 Creators:
Bezdicek, Ondrej1, Author
Ballarini, Tommaso2, Author              
Růžička, Filip1, Author
Roth, Jan1, Author
Mueller, Karsten3, Author              
Jech, Robert1, Author
Schroeter, Matthias L.2, 4, 5, Author              
Affiliations:
1Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

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Free keywords: Cognitive networks; Dorsal attention network; Eigenvector centrality; Meta-analytic co-activation maps; Mild cognitive impairment; Parkinson's disease; Resting-state functional MRI
 Abstract: Mild cognitive impairment (MCI) affects approximately one-third of non-demented Parkinson's Disease (PD) patients. We aimed at investigating the neural correlates of MCI in PD combining multimodal magnetic resonance imaging (MRI) with large-scale data from the literature. We analyzed 31 PD patients and 30 matched controls. The standard neuropsychological assessment of PD-MCI covered memory, attention, executive functions, language and visuospatial abilities. Following validated criteria, 16 patients were classified as showing MCI. Whole-brain functional connectivity and structural volume changes were assessed, respectively, by means of eigenvector centrality (EC) and voxel-based morphometry. To address the involvement of specific functional brain networks, we validated our results by building a meta-analytic co-activation map (MACM) based on the previous literature and then testing its overlap with the parcellation of functional networks derived from 1000 healthy controls. The EC comparison between PD with normal cognition and controls showed a selective decline in interconnectedness in the bilateral lentiform nuclei. Differently, comparing PD with MCI and controls revealed additional changes in non-motor areas. Directly comparing PD with and without MCI, we found a reduced interconnectedness in the bilateral superior parietal lobules and precuneus. No differences in brain volume were detected comparing these patient groups. The MACM and overlap analyses showed that the observed connectivity changes were localized in the hubs of the dorsal attention network. Notably, this aligned with the predominant attention deficit observed in our sample. Overall, functional impairment in the dorsal attention network seems to be the hallmark of MCI due to PD, thus extending previous findings of brain connectivity disruption in non-motor networks.

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Language(s): eng - English
 Dates: 2018-02-092017-12-132018-03-082018-03-112018-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuropsychologia.2018.03.011
PMID: 29540317
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : 16-13323S
Funding program : -
Funding organization : Czech Science Foundation “Micro and Macro-Connectomics of the STN nucleus”
Project name : Czech Republic Progres Q27/LF1
Grant ID : -
Funding program : -
Funding organization : Charles University
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson's Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J. Fox Foundation
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : O1GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)

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Title: Neuropsychologia
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 112 Sequence Number: - Start / End Page: 105 - 115 Identifier: ISSN: 0028-3932
CoNE: /journals/resource/954925428258