Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory

Kynast, J., Lampe, L., Luck, T., Frisch, S., Arélin, K., Hoffmann, K.-T., et al. (2018). White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory. Journal of Cerebral Blood Flow and Metabolism, 38(6), 996-1009. doi:10.1177/0271678X17719380.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:
Grün

Urheber

einblenden:
ausblenden:
 Urheber:
Kynast, Jana1, 2, Autor           
Lampe, Leonie1, 2, Autor           
Luck, Tobias2, 3, Autor
Frisch, Stefan1, 2, 4, Autor           
Arélin, Katrin1, 2, Autor           
Hoffmann, Karl-Titus2, 5, Autor
Loeffler, Markus2, 6, Autor
Riedel-Heller, Steffi G.2, 3, Autor
Villringer, Arno1, 2, 7, Autor           
Schroeter, Matthias L.1, 2, 7, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
4Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              
5Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
6Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Cognition; Magnetic resonance imaging; Small vessel disease; Vascular cognitive impairment; White matter disease
 Zusammenfassung: Age-related white matter hyperintensities (WMH) are a manifestation of white matter damage seen on magnetic resonance imaging (MRI). They are related to vascular risk factors and cognitive impairment. This study investigated the cognitive profile at different stages of WMH in a large community-dwelling sample; 849 subjects aged 21 to 79 years were classified on the 4-stage Fazekas scale according to hyperintense lesions seen on individual T2-weighted fluid-attenuated inversion recovery MRI scans. The evaluation of cognitive functioning included seven domains of cognitive performance and five domains of subjective impairment, as proposed by the DSM-5. For the first time, the impact of age-related WMH on Theory of Mind was investigated. Differences between Fazekas groups were analyzed non-parametrically and effect sizes were computed. Effect sizes revealed a slight overall cognitive decline in Fazekas groups 1 and 2 relative to healthy subjects. Fazekas group 3 presented substantial decline in social cognition, attention and memory, although characterized by a high inter-individual variability. WMH groups reported subjective cognitive decline. We demonstrate that extensive WMH are associated with specific impairment in attention, memory, social cognition, and subjective cognitive performance. The detailed neuropsychological characterization of WMH offers new therapeutic possibilities for those affected by vascular cognitive decline.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2017-05-192017-02-092017-06-072017-07-072018-06-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1177/0271678X17719380
PMID: 28685621
PMC: PMC5999004
Anderer: Epub 2017
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
Projektname : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : -
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : PDF-IRG-1307
Förderprogramm : -
Förderorganisation : Parkinson's Disease Foundation
Projektname : -
Grant ID : MJFF-11362
Förderprogramm : -
Förderorganisation : Michael J Fox Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max-Planck International Research Network on Aging (MaxNetAging)

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Cerebral Blood Flow and Metabolism
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Lippincott Williams & Wilkins
Seiten: - Band / Heft: 38 (6) Artikelnummer: - Start- / Endseite: 996 - 1009 Identifikator: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202