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  White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory

Kynast, J., Lampe, L., Luck, T., Frisch, S., Arélin, K., Hoffmann, K.-T., et al. (2018). White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory. Journal of Cerebral Blood Flow and Metabolism, 38(6), 996-1009. doi:10.1177/0271678X17719380.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F6A9-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-94AE-2
Genre: Journal Article

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 Creators:
Kynast, Jana1, 2, Author              
Lampe, Leonie1, 2, Author              
Luck, Tobias2, 3, Author
Frisch, Stefan1, 2, 4, Author              
Arélin, Katrin1, 2, Author              
Hoffmann, Karl-Titus2, 5, Author
Loeffler, Markus2, 6, Author
Riedel-Heller, Steffi G.2, 3, Author
Villringer, Arno1, 2, 7, Author              
Schroeter, Matthias L.1, 2, 7, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
4Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              
5Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
6Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Cognition; Magnetic resonance imaging; Small vessel disease; Vascular cognitive impairment; White matter disease
 Abstract: Age-related white matter hyperintensities (WMH) are a manifestation of white matter damage seen on magnetic resonance imaging (MRI). They are related to vascular risk factors and cognitive impairment. This study investigated the cognitive profile at different stages of WMH in a large community-dwelling sample; 849 subjects aged 21 to 79 years were classified on the 4-stage Fazekas scale according to hyperintense lesions seen on individual T2-weighted fluid-attenuated inversion recovery MRI scans. The evaluation of cognitive functioning included seven domains of cognitive performance and five domains of subjective impairment, as proposed by the DSM-5. For the first time, the impact of age-related WMH on Theory of Mind was investigated. Differences between Fazekas groups were analyzed non-parametrically and effect sizes were computed. Effect sizes revealed a slight overall cognitive decline in Fazekas groups 1 and 2 relative to healthy subjects. Fazekas group 3 presented substantial decline in social cognition, attention and memory, although characterized by a high inter-individual variability. WMH groups reported subjective cognitive decline. We demonstrate that extensive WMH are associated with specific impairment in attention, memory, social cognition, and subjective cognitive performance. The detailed neuropsychological characterization of WMH offers new therapeutic possibilities for those affected by vascular cognitive decline.

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Language(s): eng - English
 Dates: 2017-05-192017-02-092017-06-072017-07-072018-06-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1177/0271678X17719380
PMID: 28685621
PMC: PMC5999004
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : -
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson's Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J Fox Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 38 (6) Sequence Number: - Start / End Page: 996 - 1009 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202