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  Age-, sex-, and education-specific norms for an extended CERAD Neuropsychological Assessment Battery: Results from the population-based LIFE-Adult-Study

Luck, T., Pabst, A., Rodriguez, F. S., Schroeter, M. L., Witte, A. V., Hinz, A., et al. (2018). Age-, sex-, and education-specific norms for an extended CERAD Neuropsychological Assessment Battery: Results from the population-based LIFE-Adult-Study. Neuropsychology, 32(4), 461-475. doi:10.1037/neu0000440.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F674-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A59B-4
Genre: Journal Article

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 Creators:
Luck, Tobias1, 2, Author
Pabst, Alexander1, Author
Rodriguez, Francisca S.1, 2, 3, Author
Schroeter, Matthias L.4, 5, Author              
Witte, A. Veronica4, 6, Author              
Hinz, Andreas7, Author
Mehnert, Anja7, Author
Engel, Christoph8, Author
Loeffler, Markus8, Author
Thiery, Joachim9, Author
Villringer, Arno4, 5, Author              
Riedel-Heller, Steffi G.1, Author
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Edward R. Roybal Institute on Aging, University of Southern California, Los Angeles, CA, USA, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
7Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              
8Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
9Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              

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Free keywords: CERAD; Norms; Reference values; Neurocognitive disorder; Mild cognitive impairment
 Abstract: OBJECTIVE: To provide new age-, sex-, and education-specific reference values for an extended version of the well-established Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB) that additionally includes the Trail Making Test and the Verbal Fluency Test-S-Words. METHOD: Norms were calculated based on the cognitive performances of n = 1,888 dementia-free participants (60-79 years) from the population-based German LIFE-Adult-Study. Multiple regressions were used to examine the association of the CERAD-NAB scores with age, sex, and education. In order to calculate the norms, quantile and censored quantile regression analyses were performed estimating marginal means of the test scores at 2.28, 6.68, 10, 15.87, 25, 50, 75, and 90 percentiles for age-, sex-, and education-specific subgroups. RESULTS: Multiple regression analyses revealed that younger age was significantly associated with better cognitive performance in 15 CERAD-NAB measures and higher education with better cognitive performance in all 17 measures. Women performed significantly better than men in 12 measures and men than women in four measures. The determined norms indicate ceiling effects for the cognitive performances in the Boston Naming, Word List Recognition, Constructional Praxis Copying, and Constructional Praxis Recall tests. CONCLUSIONS: The new norms for the extended CERAD-NAB will be useful for evaluating dementia-free German-speaking adults in a broad variety of relevant cognitive domains. The extended CERAD-NAB follows more closely the criteria for the new DSM-5 Mild and Major Neurocognitive Disorder. Additionally, it could be further developed to include a test for social cognition.

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Language(s): eng - English
 Dates: 2017-10-112016-11-212017-10-152018-03-082018-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1037/neu0000440
PMID: 29517259
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
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Grant ID : -
Funding program : -
Funding organization : European Union (EU)
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Funding program : -
Funding organization : Free State of Saxony
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding program : European Social Fund
Funding organization : European Commission (EC)

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Title: Neuropsychology
Source Genre: Journal
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Publ. Info: Philadelphia, PA : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 32 (4) Sequence Number: - Start / End Page: 461 - 475 Identifier: ISSN: 0894-4105
CoNE: https://pure.mpg.de/cone/journals/resource/954925559517