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  Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient

Doll, S., Kriegmair, M. C., Santos, A., Wierer, M., Coscia, F., Neil, H. M., et al. (2018). Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient. Molecular Oncology, 12(8), 1296-1307. doi:10.1002/1878-0261.12326.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-F7D7-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-F7D8-5
Genre: Journal Article

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 Creators:
Doll, Sophia1, Author              
Kriegmair, Maximilian C.2, Author
Santos, Alberto2, Author
Wierer, Michael1, Author              
Coscia, Fabian1, Author              
Neil, Helen Michele2, Author
Porubsky, Stefan2, Author
Geyer, Philipp E.1, Author              
Mund, Andreas2, Author
Nuhn, Philipp2, Author
Mann, Matthias1, Author              
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              

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Free keywords: DNA-SEQUENCING DATA; COLORECTAL-CANCER; MASS-SPECTROMETER; RAS MUTATIONS; CELL MOTILITY; GENE SET; GENOME; CARCINOMA; GENERATION; PERIOSTINOncology; case study; clinical proteomics; epigenetics; mass spectrometry; urachal carcinoma;
 Abstract: Recent advances in mass spectrometry (MS)-based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues that allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine-specific histone demethylase 1 (LSD1/KDM1A). LSD1 is an epigenetic regulator and the target of active development efforts in oncology. Thus, clinical cancer proteomics can rapidly and efficiently identify actionable therapeutic options. While currently described for a single case study, we envision that it can be applied broadly to other patients in a similar condition.

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Language(s): eng - English
 Dates: 2018-06-142018
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000440414700006
DOI: 10.1002/1878-0261.12326
 Degree: -

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Title: Molecular Oncology
Source Genre: Journal
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Publ. Info: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY
Pages: - Volume / Issue: 12 (8) Sequence Number: - Start / End Page: 1296 - 1307 Identifier: ISSN: 1878-0261