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  In situ architecture of the algal nuclear pore complex

Mosalaganti, S., Kosinski, J., Albert, S., Schaffer, M., Strenkert, D., Salome, P. A., et al. (2018). In situ architecture of the algal nuclear pore complex. Nature Communications, 9: 2361. doi:10.1038/s41467-018-04739-y.

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 Urheber:
Mosalaganti, Shyamal1, Autor
Kosinski, Jan1, Autor
Albert, Sahradha2, Autor           
Schaffer, Miroslava2, Autor           
Strenkert, Daniela1, Autor
Salome, Patrice A.1, Autor
Merchant, Sabeeha S.1, Autor
Plitzko, Jürgen M.3, Autor           
Baumeister, Wolfgang2, Autor           
Engel, Benjamin D.2, Autor           
Beck, Martin1, Autor
Affiliations:
1external, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
3Department of Microbiology, Max Planck Institute for Marine Microbiology, Max Planck Society, ou_2481695              

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Schlagwörter: CRYOELECTRON TOMOGRAPHY; STRUCTURAL-ANALYSIS; MOLECULAR ARCHITECTURE; ELECTRON-MICROSCOPY; MEMBRANE-PROTEINS; INNER RING; EVOLUTION; DYNAMICS; SCAFFOLD; REVEALSScience & Technology - Other Topics;
 Zusammenfassung: Nuclear pore complexes (NPCs) span the nuclear envelope and mediate nucleocytoplasmic exchange. They are a hallmark of eukaryotes and deeply rooted in the evolutionary origin of cellular compartmentalization. NPCs have an elaborate architecture that has been well studied in vertebrates. Whether this architecture is unique or varies significantly in other eukaryotic kingdoms remains unknown, predominantly due to missing in situ structural data. Here, we report the architecture of the algal NPC from the early branching eukaryote Chlamydomonas reinhardtii and compare it to the human NPC. We find that the inner ring of the Chlamydomonas NPC has an unexpectedly large diameter, and the outer rings exhibit an asymmetric oligomeric state that has not been observed or predicted previously. Our study provides evidence that the NPC is subject to substantial structural variation between species. The divergent and conserved features of NPC architecture provide insights into the evolution of the nucleocytoplasmic transport machinery.

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Sprache(n): eng - English
 Datum: 2018
 Publikationsstatus: Online veröffentlicht
 Seiten: 8
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000435451000002
DOI: 10.1038/s41467-018-04739-y
 Art des Abschluß: -

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Titel: Nature Communications
  Kurztitel : Nat. Commun.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 9 Artikelnummer: 2361 Start- / Endseite: - Identifikator: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723