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  Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?

Konstantinidou, M., Zarganes-Tzitzikas, T., Magiera-Mularz, K., Holak, T. A., & Domling, A. (2018). Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies? Angewandte Chemie International Edition, 57(18), 4840-4848. doi:10.1002/anie.201710407.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C75B-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C75C-7
Genre: Journal Article

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 Creators:
Konstantinidou, Markella1, Author
Zarganes-Tzitzikas, Tryfon1, Author
Magiera-Mularz, Katarzyna1, Author
Holak, Tad A.2, Author              
Domling, Alexander1, Author
Affiliations:
1external, ou_persistent22              
2Holak, Tad / NMR Spectroscopy, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565154              

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Free keywords: PROGRAMMED DEATH-1; STRUCTURAL BASIS; CANCER-IMMUNOTHERAPY; CRYSTAL-STRUCTURE; HUMAN PD-1; CELL; INHIBITORS; BLOCKADE; LIGANDS; COMPLEXChemistry; antitumor agents; protein-protein interactions; PD-1; PD-L1; protein structures;
 Abstract: The PD-1/PD-L1 interaction has emerged as a significant target in cancer immunotherapy. Current medications include monoclonal antibodies, which have shown impressive clinical results in the treatment of several types of tumors. The cocrystal structure of human PD-1 and PD-L1 is expected to be a valuable starting point for the design of novel inhibitors, along with the recent crystal structures with monoclonal antibodies, small molecules, and macrocycles.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000432382800005
DOI: 10.1002/anie.201710407
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Other : Angew. Chem. Int. Ed.
Source Genre: Journal
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Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 57 (18) Sequence Number: - Start / End Page: 4840 - 4848 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851