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  Addressing cellular compartmentalization by in situ cryo-electron tomography

Erdmann, P. S., Plitzko, J. M., & Baumeister, W. (2018). Addressing cellular compartmentalization by in situ cryo-electron tomography. Current Opinion in Colloid & Interface Science, 34, 89-99. doi:10.1016/j.cocis.2018.05.003.

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 Creators:
Erdmann, Philipp S.1, Author              
Plitzko, Jürgen M.1, Author              
Baumeister, Wolfgang1, Author              
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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Free keywords: TRANSMISSION ELECTRON-MICROSCOPY; LOCALIZATION MICROSCOPY; MULTICELLULAR ORGANISMS; MOLECULAR SOCIOLOGY; STRUCTURAL-ANALYSIS; VITREOUS SECTIONS; ATOMIC-RESOLUTION; CRYO-EM; RECONSTRUCTION; NUCLEARChemistry;
 Abstract: Atomic resolution structures have provided us with fascinating views and insights into the molecular architecture of many cellular components. At the same time, we have not exploited information on the interaction of these molecular players within their native environment, because conventional high resolution techniques demand fractionation and purification of cellular constituents. In situ cryo-electron tomography is about to change that. Significant advances in hardware instrumentation and sample preparation now reveal the cellular landscape in exquisite detail and at molecular resolution. We here review the technological developments that have enabled this highly visual approach, taking count of cellular constituents within close-to-life preparations.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Current Opinion in Colloid & Interface Science
  Other : Curr. Opin. Colloid Interface Sci.
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 34 Sequence Number: - Start / End Page: 89 - 99 Identifier: ISSN: 1359-0294
CoNE: https://pure.mpg.de/cone/journals/resource/954925619127