English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Feasibility of Functional MRI at Ultralow Magnetic Field via Changes in Cerebral Blood Volume

Buckenmaier, K., Pedersen, A., SanGiorgio, P., Scheffler, K., Clarke, J., & Inglis, B. (2019). Feasibility of Functional MRI at Ultralow Magnetic Field via Changes in Cerebral Blood Volume. NeuroImage, 186, 185-191. doi:10.1016/j.neuroimage.2018.10.071.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-0215-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-7AA4-C
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Buckenmaier, K, Author              
Pedersen, A, Author
SanGiorgio, P, Author
Scheffler, K1, 2, Author              
Clarke, J, Author
Inglis, B, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Content

show
hide
Free keywords: -
 Abstract: We investigate the feasibility of performing functional MRI (fMRI) at ultralow field (ULF) with a Superconducting QUantum Interference Device (SQUID), as used for detecting magnetoencephalography (MEG) signals from the human head. While there is negligible magnetic susceptibility variation to produce blood oxygenation level-dependent (BOLD) contrast at ULF, changes in cerebral blood volume (CBV) may be a sensitive mechanism for fMRI given the five-fold spread in spin-lattice relaxation time (T1) values across the constituents of the human brain. We undertook simulations of functional signal strength for a simplified brain model involving activation of a primary cortical region in a manner consistent with a blocked task experiment. Our simulations involve measured values of T1 at ULF and experimental parameters for the performance of an upgraded ULFMRI scanner. Under ideal experimental conditions we predict a functional signal-to-noise ratio of between 3.1 and 7.1 for an imaging time of 30 minutes, or between 1.5 and 3.5 for a blocked task experiment lasting 7.5 minutes. Our simulations suggest it may be feasible to perform fMRI using a ULFMRI system designed to perform MRI and MEG in situ.

Details

show
hide
Language(s):
 Dates: 2018-072018-102019-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 186 Sequence Number: - Start / End Page: 185 - 191 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166