English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  DNA nanotweezers and graphene transistor enable label-free genotyping.

Hwang, M. T., Wang, Z., Ping, J., Ban, D. K., Shiah, Z. C., Antonschmidt, L., et al. (2018). DNA nanotweezers and graphene transistor enable label-free genotyping. Advanced Materials, 30(34): 1802440. doi:10.1002/adma.201802440.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-054E-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6769-4
Genre: Journal Article

Files

show Files
hide Files
:
2639355.pdf (Publisher version), 3MB
 
File Permalink:
-
Name:
2639355.pdf
Description:
-
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2639355_Suppl.pdf (Supplementary material), 601KB
Name:
2639355_Suppl.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Hwang, M. T., Author
Wang, Z., Author
Ping, J., Author
Ban, D. K., Author
Shiah, Z. C., Author
Antonschmidt, L.1, Author              
Lee, J., Author
Liu, Y., Author
Karkisaval, A. G., Author
Johnson, A. T. C., Author
Fan, C., Author
Glinsky, G., Author
Lal, R., Author
Affiliations:
1Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              

Content

show
hide
Free keywords: DNA strand displacement; DNA tweezers; electrical wireless biosensor; graphene FET biosensor; single nucleotide polymorphism (SNP) detection
 Abstract: Electronic DNA-biosensor with a single nucleotide resolution capability is highly desirable for personalized medicine. However, existing DNA-biosensors, especially single nucleotide polymorphism (SNP) detection systems, have poor sensitivity and specificity and lack real-time wireless data transmission. DNA-tweezers with graphene field effect transistor (FET) are used for SNP detection and data are transmitted wirelessly for analysis. Picomolar sensitivity of quantitative SNP detection is achieved by observing changes in Dirac point shift and resistance change. The use of DNA-tweezers probe with high-quality graphene FET significantly improves analytical characteristics of SNP detection by enhancing the sensitivity more than 1000-fold in comparison to previous work. The electrical signal resulting from resistance changes triggered by DNA strand-displacement and related changes in the DNA geometry is recorded and transmitted remotely to personal electronics. Practical implementation of this enabling technology will provide cheaper, faster, and portable point-of-care molecular health status monitoring and diagnostic devices.

Details

show
hide
Language(s): eng - English
 Dates: 2018-07-092018-08-23
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/adma.201802440
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advanced Materials
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 9 Volume / Issue: 30 (34) Sequence Number: 1802440 Start / End Page: - Identifier: -