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  Facilitated event-related power modulations during transcranial alternating current stimulation (tACS) revealed by concurrent tACSMEG

Kasten, F. H., Maess, B., & Herrmann, C. S. (2018). Facilitated event-related power modulations during transcranial alternating current stimulation (tACS) revealed by concurrent tACSMEG. eNeuro, 5(3): e0069-18. doi:10.1523/ENEURO.0069-18.2018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-0942-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-94C1-B
Genre: Journal Article

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Kasten_Maess_Herrmann_2018.pdf (Publisher version), 3MB
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 Creators:
Kasten, Florian H.1, 2, Author
Maess, Burkhard3, Author              
Herrmann, Christoph S.1, 2, 4, Author
Affiliations:
1Cluster of Excellence “Hearing4all”, Department of Psychology, Carl von Ossietzky University of Oldenburg, Germany, ou_persistent22              
2Neuroimaging Unit, European Medical School, Carl von Ossietzky University of Oldenburg, Germany, ou_persistent22              
3Methods and Development Group MEG and EEG - Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205650              
4Research Centre Neurosensory Science, Carl von Ossietzky University of Oldenburg, Germany, ou_persistent22              

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Free keywords: Cognitive performance; Event-related oscillations; MEG; Online effects; Transcranial alternating current stimulation (tACS)
 Abstract: Non-invasive approaches to modulate oscillatory activity in the brain are increasingly popular in the scientific community. Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations in a frequency-specific manner. However, due to a massive stimulation artifact at the targeted frequency, little is known about effects of tACS during stimulation. It remains unclear how the continuous application of tACS affects event-related oscillations during cognitive tasks. Depending on whether tACS influences pre- or post-stimulus oscillations, or both, the endogenous, event-related oscillatory dynamics could be pushed in various directions or not at all. A better understanding of these effects is crucial to plan, predict, and understand outcomes of solely behavioral tACS experiments. In the present study, a recently proposed procedure to suppress tACS artifacts by projecting MEG data into source-space using spatial filtering was utilized to recover event-related power modulations in the alpha-band during a mental rotation task. MEG data of 25 human subjects was continuously recorded. After 10-minute baseline measurement, participants received either 20 minutes of tACS at their individual alpha frequency or sham stimulation. Another 40 minutes of MEG data were acquired thereafter. Data were projected into source-space and carefully examined for residual artifacts. Results revealed strong facilitation of event-related power modulations in the alpha-band during tACS application. These results provide first direct evidence that tACS does not counteract top-down suppression of intrinsic oscillations, but rather enhances pre-existent power modulations within the range of the individual alpha (= stimulation) frequency.

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Language(s): eng - English
 Dates: 2018-06-012018-02-132018-06-072018-06-25
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/ENEURO.0069-18.2018
PMID: 30073188
PMC: PMC6070188
Other: eCollection 2018
PII: ENEURO.0069-18.2018
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Project name : Resolving and Manipulating Neuronal Networks in the Mammalian Brain - from Correlative to Causal Analysis / SPP 1665
Grant ID : HE 3353/8-2
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: eNeuro
Source Genre: Journal
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Publ. Info: Washington, DC : Society for Neuroscience
Pages: - Volume / Issue: 5 (3) Sequence Number: e0069-18 Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/106249492X