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  WOME: Theory-based working memory training - A placebo-controlled, double-blind evaluation in older adults

Weicker, J., Hudl, N., Frisch, S., Lepsien, J., Mueller, K., Villringer, A., et al. (2018). WOME: Theory-based working memory training - A placebo-controlled, double-blind evaluation in older adults. Frontiers in Aging Neuroscience, 10: 247. doi:10.3389/fnagi.2018.00247.

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 Creators:
Weicker, Juliane1, 2, Author           
Hudl, Nicole3, Author
Frisch, Stefan2, 4, Author           
Lepsien, Jöran5, Author           
Mueller, Karsten5, Author           
Villringer, Arno1, 2, Author           
Thöne-Otto, Angelika I. T.1, Author           
Affiliations:
1Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Max Planck International Research Network on Aging (MaxNetAging), Rostock, Germany, ou_persistent22              
4Department of Psychology, Goethe University, Frankfurt, Germany, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Working memory training; Cognitive training; Plasticity, aging; Neuropsychology; Rehabilitation; Cognitive decline; Mild cognitive impairment
 Abstract: Background: Scientifically evaluated cognitive intervention programs are essential to meet the demands of our increasingly aging society. Currently, one of the "hottest" topics in the field is the improvement of working memory function and its potential impact on overall cognition. The present study evaluated the efficacy of WOME (WOrking MEmory), a theory-based working memory training program, in a double-blind, placebo-controlled, and randomized controlled trial (www.drks.de, DRKS00013162). Methods:N = 60 healthy older adults were allocated to (1) the WOME intervention, (2) an active low-level intervention, or (3) a passive control group. Overall, the intervention groups practiced twelve sessions of 45 min within 4 weeks of their respective training. Transfer effects were measured via an extensive battery of neuropsychological tests and questionnaires both pre-/post-training and at a 3-month follow-up. Results:WOME led to a significant improvement in working memory function, demonstrated on a non-trained near transfer task and on two different composite scores with moderate to large effect sizes. In addition, we found some indication of relevant impact on everyday life. The effects were short-term rather than stable, being substantially diminished at follow-up with only little evidence suggesting long-term maintenance. No transfer effects on other cognitive functions were observed. Conclusion:WOME is an appropriate and efficient intervention specifically targeting the working memory system in healthy older adults.

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Language(s): eng - English
 Dates: 2018-05-032018-07-272018-08-14
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnagi.2018.00247
PMID: 30154713
PMC: PMC6102413
Other: eCollection 2018
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Funding organization : Max Planck Society
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Funding organization : FAZIT-Stiftung
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Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)

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Title: Frontiers in Aging Neuroscience
  Abbreviation : Front Aging Neurosci
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 247 Start / End Page: - Identifier: ISSN: 1663-4365
CoNE: https://pure.mpg.de/cone/journals/resource/1663-4365