English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Polo on the rise-from mitotic entry to cytokinesis with Plk1.

Petronczki, M., Lenart, P., & Peters, J. M. (2008). Polo on the rise-from mitotic entry to cytokinesis with Plk1. Developmental Cell, 14(5), 646-659. doi:10.1016/j.devcel.2008.04.014.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-0F0A-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-0F14-8
Genre: Journal Article

Files

show Files
hide Files
:
2640479.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
2640479.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute), Göttingen; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Petronczki, M., Author
Lenart, P.1, Author              
Peters, J. M., Author
Affiliations:
1Research Group of Cytoskeletal Dynamics in Oocytes, MPI for Biophysical Chemistry, Max Planck Society, ou_2640691              

Content

show
hide
Free keywords: -
 Abstract: Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New techniques, including the application of small-molecule inhibitors, have greatly expanded our knowledge of the functions, targets, and regulation of this key mitotic enzyme. In this review, we focus on how Plk1 is recruited to centrosomes, kinetochores, and the spindle midzone and what the specific tasks of Plk1 at these distinct subcellular structures might be. In particular, we highlight new work on the role of Plk1 in cytokinesis in human cells. Finally, we describe how better understanding of Plk1 functions allows critical evaluation of Plk1 as a potential drug target for cancer therapy.

Details

show
hide
Language(s): eng - English
 Dates: 2008-05-122008-05-13
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.devcel.2008.04.014
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Developmental Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 14 (5) Sequence Number: - Start / End Page: 646 - 659 Identifier: -