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  Dynamics of nuclear pore complex organization through the cell cycle.

Rabut, G., Lenart, P., & Ellenberg, J. (2004). Dynamics of nuclear pore complex organization through the cell cycle. Current Opinion in Cell Biology, 16(3), 314-321. doi:10.1016/j.ceb.2004.04.001.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-1135-F Version Permalink: http://hdl.handle.net/21.11116/0000-0002-1138-C
Genre: Journal Article

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2641788.pdf (Publisher version), 221KB
 
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Rabut, G., Author
Lenart, P.1, Author              
Ellenberg, J., Author
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1Research Group of Cytoskeletal Dynamics in Oocytes, MPI for Biophysical Chemistry, Max Planck Society, ou_2640691              

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 Abstract: In eukaryotic cells, all macromolecules that traffic between the nucleus and the cytoplasm cross the double nuclear membrane through nuclear pore complexes (NPCs). NPCs are elaborate gateways that allow efficient, yet selective, translocation of many different macromolecules. Their protein composition has been elucidated, but how exactly these nucleoporins come together to form the pore is largely unknown. Recent data suggest that NPCs are composed of an extremely stable scaffold on which more dynamic, exchangeable parts are assembled. These could be targets for molecular rearrangements that change nuclear pore transport properties and, ultimately, the state of the cell.

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Language(s): eng - English
 Dates: 2004-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.ceb.2004.04.001
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Title: Current Opinion in Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 16 (3) Sequence Number: - Start / End Page: 314 - 321 Identifier: -