Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.

Hagiwara, A., Kitahara, Y., Grabner, C., Vogl, C., Abe, M., Kitta, R., et al. (2018). Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance. Journal of Cell Biology, 217(11), 3993-4006. doi:10.1083/jcb.201704076.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
2642033.pdf (Verlagsversion), 3MB
Name:
2642033.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Hagiwara, A., Autor
Kitahara, Y., Autor
Grabner, C.1, Autor           
Vogl, C., Autor
Abe, M., Autor
Kitta, R., Autor
Ohta, K., Autor
Nakamura, K., Autor
Sakimura, K., Autor
Moser, T.1, Autor           
Nishi, A., Autor
Ohtsuka, T., Autor
Affiliations:
1Research Group of Synaptic Nanophysiology, MPI for Biophysical Chemistry, Max Planck Society, ou_2205655              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: At the presynaptic active zone (AZ), the related cytomatrix proteins CAST and ELKS organize the presynaptic release machinery. While CAST is known to regulate AZ size and neurotransmitter release, the role of ELKS and the integral system of CAST/ELKS together is poorly understood. Here, we show that CAST and ELKS have both redundant and unique roles in coordinating synaptic development, function, and maintenance of retinal photoreceptor ribbon synapses. A CAST/ELKS double knockout (dKO) mouse showed high levels of ectopic synapses and reduced responses to visual stimulation. Ectopic formation was not observed in ELKS conditional KO but progressively increased with age in CAST KO mice with higher rates in the dKO. Presynaptic calcium influx was strongly reduced in rod photoreceptors of CAST KO and dKO mice. Three-dimensional scanning EM reconstructions showed structural abnormalities in rod triads of CAST KO and dKO. Remarkably, AAV-mediated acute ELKS deletion after synapse maturation induced neurodegeneration and loss of ribbon synapses. These results suggest that CAST and ELKS work in concert to promote retinal synapse formation, transmission, and maintenance.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2018-09-062018-11-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1083/jcb.201704076
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Cell Biology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 217 (11) Artikelnummer: - Start- / Endseite: 3993 - 4006 Identifikator: -