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  Dynamic metabolic changes in human visual cortex in regions with positive and negative blood oxygenation level-dependent response

Martínez-Maestro, M., Labadie, C., & Möller, H. E. (2019). Dynamic metabolic changes in human visual cortex in regions with positive and negative blood oxygenation level-dependent response. Journal of Cerebral Blood Flow and Metabolism, 39(11), 2295-2307. doi:10.1177/0271678X18795426.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-11CA-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F5ED-D
Genre: Journal Article

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 Creators:
Martínez-Maestro, Miguel1, Author              
Labadie, Christian2, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Functional magnetic resonance spectroscopy; Glucose, glutamate; Positive blood oxygenation level-dependent response; Negative blood oxygenation level-dependent response
 Abstract: Dynamic metabolic changes were investigated by functional magnetic resonance spectroscopy (fMRS) during sustained stimulation of human primary visual cortex. Two established paradigms, consisting of either a full-field or a small-circle flickering checkerboard, were employed to generate wide-spread areas of positive or negative blood oxygenation level-dependent (BOLD) responses, respectively. Compared to baseline, the glutamate concentration increased by 5.3% (p = 0.007) during activation and decreased by −3.8% (p = 0.017) during deactivation. These changes were positively correlated with the amplitude of the BOLD response (R = 0.60, p = 0.002) and probably reflect changes of tricarboxylic acid cycle activity. During deactivation, the glucose concentration decreased by −7.9% (p = 0.025) presumably suggesting increased consumption or reduced glucose supply. Other findings included an increased concentration of glutathione (4.2%, p = 0.023) during deactivation and a negative correlation of glutathione and BOLD signal changes (R = −0.49, p = 0.012) as well as positive correlations of aspartate (R = 0.44, p = 0.035) and N-acetylaspartylglutamate (R = 0.42, p = 0.035) baseline concentrations with the BOLD response. It remains to be shown in future work if the observed effects on glutamate and glucose levels deviate from the assumption of a direct link between glucose utilization and regulation of blood flow or support previous suggestions that the hemodynamic response is mainly driven by feedforward release of vasoactive messengers.

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Language(s): eng - English
 Dates: 2018-04-132018-07-292018-08-172019-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1177/0271678X18795426
PMID: 30117749
Other: Epub 2018
 Degree: -

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Project name : Transforming Magnetic Resonance Spectroscopy into a Clinical Tool / TRANSACT
Grant ID : 316679
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : HA-314
Funding program : -
Funding organization : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
 Creator(s):
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 39 (11) Sequence Number: - Start / End Page: 2295 - 2307 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202