Neuronal activity in the rat prelimbic prefrontal cortex and cingulate cortex 
during a sustained attention task

Totah, NK; Homayoun, H; Moghaddam, B

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Neuronal activity in the rat prelimbic prefrontal cortex and cingulate cortex during a sustained attention task

Totah, N., Homayoun, H., & Moghaddam, B. (2007). Neuronal activity in the rat prelimbic prefrontal cortex and cingulate cortex during a sustained attention task. Poster presented at 37th Annual Meeting of the Society for Neuroscience (Neuroscience 2007), San Diego, CA, USA.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-11E2-B Version Permalink: https://hdl.handle.net/21.11116/0000-0003-92AE-4

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http://www.sfn.org/annual-meeting/past-and-future-annual-meetings (Table of contents) Open Access status unknown

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Totah, NK¹, Author
Homayoun, H, Author
Moghaddam, B, Author

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1Department of Neuroscience, University of Pittsburgh, ou_persistent22

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Abstract: Attention is a critical component of normal cognitive functioning that requires the prefrontal cortex. Lesion studies in rats suggest that the medial prefrontal (mPFC) and anterior cingulate (ACg) sub-regions are both involved in controlling attention. However, little is known about how cells in these regions encode different aspects of attentional processing. We have developed the 3-choice serial reaction time task (CSRT), which is an analog of the 5-CSRT task used to study visual attention in the rat. The task requires a rat to divide attention between 3 brief light stimuli (300 msec duration) presented in random order across nose poke holes in an operant conditioning chamber. A correct response into a lit cue results in a reward delivery, while an incorrect response into an unlit cue or a missed response is punished with house-light extinguishment. We are studying the neuronal correlates of visual attention and response monitoring in the prelimbic region of the mPFC and the ACg. Single unit activity and local field potentials (LFP) are recorded during task performance and the neuronal correlates of relevant task events are compared between regions. We are also using distracting stimuli to increase attentional load and studying its effects on the neural correlates of attention using a within-session design. We predict that our analysis will reveal task relevant phasic responses that differ between the ACg and the prelimbic mPFC at the single-unit and population levels. These experiments will help further our understanding of the prefrontal cortical processes that regulate the allocation of attention during normal conditions and in face of increased cognitive demands.

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Dates: Date issued: 2007-11

Publication Status: Issued

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Title: 37th Annual Meeting of the Society for Neuroscience (Neuroscience 2007)

Place of Event: San Diego, CA, USA

Start-/End Date: 2007-11-03 - 2007-11-07

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Title: 37th Annual Meeting of the Society for Neuroscience (Neuroscience 2007)

Source Genre: Proceedings

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Pages: - Volume / Issue: - Sequence Number: 741.5 Start / End Page: - Identifier: -