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  Epigenetic variance in dopamine D2 receptor: A marker of IQ malleability?

Kaminski, J. A., Schlagenhauf, F., Rapp, M., Awasthi, S., Ruggeri, B., Deserno, L., et al. (2018). Epigenetic variance in dopamine D2 receptor: A marker of IQ malleability? Translational Psychiatry, 8: 169. doi:10.1038/s41398-018-0222-7.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-1480-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9A03-C
Genre: Journal Article

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 Creators:
Kaminski, Jakob A. 1, 2, Author
Schlagenhauf, Florian1, 3, Author              
Rapp, Michael1, 4, Author
Awasthi, Swapnil1, 5, Author
Ruggeri, Barbara 6, Author
Deserno, Lorenz1, 3, 7, Author              
Banaschewski, Tobias8, Author
Bokde, Arun L. W.9, Author
Bromberg, Uli10, Author
Büchel , Christian 10, Author
Quinlan, Erin Burke 11, Author
Desrivières, Sylvane 12, Author
Flor, Herta12, 13, Author
Frouin, Vincent 14, Author
Garavan, Hugh 15, Author
Gowland , Penny16, Author
Ittermann, Bernd 17, Author
Martinot, Jean-Luc 18, Author
Paillère Martinot, Marie-Laure19, Author
Nees, Frauke 8, 12, Author
Orfanos, Dimitri Papadopoulos 14, AuthorPaus, Tomáš20, AuthorPoustka, Luise 8, 21, AuthorSmolka, Michael N. 22, AuthorFröhner, Juliane H. 22, AuthorWalter, Henrik1, AuthorWhelan, Robert 23, AuthorRipke, Stephan 1, 5, AuthorSchumann, Gunter 11, AuthorHeinz, Andreas 1, AuthorThe IMAGEN Consortium, Author               more..
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Berlin Institute of Health (BIH), Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
5Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA, ou_persistent22              
6Centre for Neuroimaging Science, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
7Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Germany, ou_persistent22              
8Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
9Institute of Neuroscience, Trinity College Dublin, Ireland, ou_persistent22              
10University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
11Social, Genetic and Developmental Psychiatry Centre (MRC), Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
12Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
13Department of Psychology, School of Social Sciences, University of Mannheim, Germany, ou_persistent22              
14Neurospin Center, Institut national de la santé et de la recherche médicale, Paris, France, ou_persistent22              
15Department of Psychiatry, University of Vermont, Burlington, VT, USA, ou_persistent22              
16Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              
17Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, ou_persistent22              
18Neuroimaging and Psychiatry, Institut national de la santé et de la recherche médicale, Paris, France, ou_persistent22              
19Cochin Hospital, Paris, France, ou_persistent22              
20Rotman Research Institute, University of Toronto, ON, Canada, ou_persistent22              
21Department of Child and Adolescent Psychiatry, Medical University of Vienna, Wien, Austria, ou_persistent22              
22Neuroimaging Center, TU Dresden, Germany, ou_persistent22              
23School of Psychology, Trinity College Dublin, Ireland, ou_persistent22              

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 Abstract: Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the “missing heritability” between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.

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Language(s): eng - English
 Dates: 2018-06-142017-09-192018-07-142018-08-30
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41398-018-0222-7
PMID: 30166545
PMC: PMC6117339
 Degree: -

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Funding program : FP6 (LSHM-CT-2007-037286)
Funding organization : European Commission (EC)

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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
 Creator(s):
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 8 Sequence Number: 169 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188