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  Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex

Urban, N. N., González−Burgos, G. R., Henze, D. A., Lewis, D. A., & Barrionuevo, G. (2002). Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex. The Journal of Physiology - London, 539(3), 707-712. doi:10.1113/jphysiol.2001.015024.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-14E2-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-14E3-7
Genre: Journal Article

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JPhysiol_539_2002_707.pdf (Any fulltext), 221KB
 
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https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/jphysiol.2001.015024 (Any fulltext)
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 Creators:
Urban, Nathaniel N.1, Author           
González−Burgos, Guillermo R., Author
Henze, Darrell A., Author
Lewis, David A., Author
Barrionuevo, German, Author
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: We have employed in vitro physiological methods to investigate dopaminergic modulation of excitatory synaptic transmission in monkey prefrontal cortex (PFC) circuits. We show that combined activation of D1-like and D2-like dopamine receptors results in the reduction of extracellular stimulation-evoked isolated EPSCs in layer 3 pyramidal neurons. Using paired recordings from synaptically connected pyramidal neurons we have determined the basic properties of unitary synaptic connections between layer 3 pyramids in the primate PFC and, interestingly, we found that dopamine does not reduce synaptic transmission between nearby pairs of synaptically coupled PFC pyramidal neurons. This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC.

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Language(s): eng - English
 Dates: 2001-12-042002-01-302002-02-082002-03-15
 Publication Status: Issued
 Pages: 6
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1113/jphysiol.2001.015024
URI: http://www.ncbi.nlm.nih.gov/pubmed/11897842
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Title: The Journal of Physiology - London
Source Genre: Journal
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Publ. Info: London : Cambridge University Press
Pages: - Volume / Issue: 539 (3) Sequence Number: - Start / End Page: 707 - 712 Identifier: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693_2