English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  How Active Mechanics and Regulatory Biochemistry Combine to Form Patterns in Development.

Gross, P., Kumar, K. V., & Grill, S. W. (2017). How Active Mechanics and Regulatory Biochemistry Combine to Form Patterns in Development. Annual review of biophysics, 46, 337-356. doi:10.1146/annurev-biophys-070816-033602.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gross, Peter1, Author           
Kumar, K Vijay, Author
Grill, Stephan W.1, Author           
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, ou_2340692              

Content

show
hide
Free keywords: -
 Abstract: The development of organisms starting from their zygotic state involves a tight integration of the myriad biochemical signaling interactions with the mechanical forces that eventually pattern and shape the resulting embryo. In the past decade, it has become increasingly evident that several important developmental processes involve mechanical forces in an essential manner. In this review, we highlight the multifaceted role of mechanics in pattern formation, from protein and cell sorting to the generation of tissue shape. We then review the ways in which the active cellular cytoskeleton self-organizes to form dynamic patterns. Finally, we focus on mechanochemical feedback, where signaling proteins can establish patterns via coupling to the activity of the cytoskeleton. Throughout the review, we focus on the generic physical principles of the establishment of active mechanochemical patterns and point toward future directions in studying how the principles of mechanics and chemistry combine to drive morphogenetic pattern formation.

Details

show
hide
Language(s):
 Dates: 2017-05-22
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1146/annurev-biophys-070816-033602
Other: cbg-6869
PMID: 28532214
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Annual review of biophysics
  Other : Ann Rev Biophys
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 46 Sequence Number: - Start / End Page: 337 - 356 Identifier: -