RNA gets in phase.

Saha, Shambaditya; Hyman, Anthony

doi:10.1083/jcb.201706034

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RNA gets in phase.

Saha, S., & Hyman, A. (2017). RNA gets in phase. The Journal of cell biology, 216(8), 2235-2237. doi:10.1083/jcb.201706034.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-8CB2-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-8CB3-6

Genre: Journal Article

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Creators:
Saha, Shambaditya¹, Author
Hyman, Anthony¹, Author

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1Max Planck Institute for Molecular Cell Biology and Genetics, ou_2340692

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Abstract: Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https://doi.org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity.

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Dates: Date issued: 2017-08-07

Publication Status: Issued

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Identifiers: DOI: 10.1083/jcb.201706034
Other: cbg-6925
PMID: 28667121

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Title: The Journal of cell biology

Other : J Cell Biol

Source Genre: Journal

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Pages: - Volume / Issue: 216 (8) Sequence Number: - Start / End Page: 2235 - 2237 Identifier: -