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  Uniform gene expression in embryos is achieved by temporal averaging of transcription noise.

Stapel, L. C., Zechner, C., & Vastenhouw, N. (2017). Uniform gene expression in embryos is achieved by temporal averaging of transcription noise. Genes & development, 31(16), 1635-1640. doi:10.1101/gad.302935.117.

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Stapel, L Carine1, Author           
Zechner, Christoph1, Author           
Vastenhouw, Nadine1, Author           
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, ou_2340692              

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 Abstract: Transcription is often stochastic. This is seemingly incompatible with the importance of gene expression during development. Here we show that during zebrafish embryogenesis, transcription activation is stochastic due to (1) genes acquiring transcriptional competence at different times in different cells, (2) differences in cell cycle stage between cells, and (3) the stochastic nature of transcription. Initially, stochastic transcription causes large cell-to-cell differences in transcript levels. However, variability is reduced by lengthening cell cycles and the accumulation of transcription events in each cell. Temporal averaging might provide a general context in which to understand how embryos deal with stochastic transcription.

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 Dates: 2017-08-15
 Publication Status: Issued
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 Identifiers: DOI: 10.1101/gad.302935.117
Other: cbg-6944
PMID: 28903980
 Degree: -

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Title: Genes & development
  Other : Genes Dev
Source Genre: Journal
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Pages: - Volume / Issue: 31 (16) Sequence Number: - Start / End Page: 1635 - 1640 Identifier: -