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  Charge-controlled synthetic hyaluronan-based cell matrices

Hegger, P., Kupka, J., Baykal Minsky, B., Laschat, S., & Böhm, H. (2018). Charge-controlled synthetic hyaluronan-based cell matrices. Molecules, 23(4), 1-13. doi:10.3390/molecules23040769.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-1B56-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-79B8-7
Genre: Journal Article
Alternative Title : Molecules_23_2018_

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Molecules_23_2018_1.pdf (Any fulltext), 6MB
 
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 Creators:
Hegger, Patricia1, 2, Author              
Kupka, Julia, Author
Baykal Minsky, Burcu1, 2, Author              
Laschat, Sabine, Author
Böhm, Heike1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: hyaluronan; polyelectrolyte hydrogel; enzymatic degradation; synthetic ECM; cell attachment; glycosaminoglycans; tissue engineering
 Abstract: The extracellular matrix (ECM) represents a highly charged and hydrated network in which different cells in vertebrate tissues are embedded. Hydrogels as minimal ECM mimetics with a controlled chemistry offer the opportunity to vary material properties by varying the negative network charge. In this paper, a synthetic biology model of the ECM based on natural and highly negatively charged polyelectrolyte hyaluronic acid (HA) is characterized with specific emphasis on its charge-related bioactivity. Therefore, the thiol-Michael addition click reaction is used to produce HA hydrogels with defined network structure and charge density. The presented hydrogels show enzymatic degradability and cell attachment. These properties depend on both covalent and electrostatic interactions within the hydrogel network. Furthermore, no unspecific or specific attachment of proteins to the presented hydrogels is observed. In addition, these fundamental insights into charge-related ECM behavior and the influence of electrostatic properties could also lead to innovations in existing biomedical products.

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Language(s): eng - English
 Dates: 2018-02-212018-03-232018-03-272018-03-27
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Molecules
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 23 (4) Sequence Number: - Start / End Page: 1 - 13 Identifier: ISSN: 1420-3049
CoNE: https://pure.mpg.de/cone/journals/resource/954925623244