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  AGuIX® from bench to bedside: Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V., Thomas, E., Dufort, S., Rossetti, F., Martini, M., et al. (2019). AGuIX® from bench to bedside: Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. British Journal of Radiology, 92(1093): 20180365, pp. 1-19. doi:10.1259/bjr.20180365.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-1BDF-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-B3A7-7
Genre: Journal Article

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 Creators:
Lux, F, Author
Tran, VL, Author
Thomas, E, Author
Dufort, S, Author
Rossetti, F, Author
Martini, M, Author
Truillet, C, Author
Doussineau, T, Author
Bort, G, Author
Denat, F, Author
Boschetti, F, Author
Angelovski, G1, 2, Author              
Detappe, A, Author
Crémillieux , Y, Author
Mignet, M, Author
Doan, BT, Author
Larrat, B, Author
Meriaux, S, Author
Barbier, E, Author
Roux, S, Author
Fries, P, AuthorMüller, A, AuthorAbadjian, MC, AuthorAnderson, C, AuthorCanet-Soulas, E, AuthorBouziotis, P, AuthorBarberi-Heyob, M, AuthorVerry, C, AuthorBalosso , J, AuthorEvans, M, AuthorSidi-Boumedine, J, AuthorJanier, M, AuthorButterworth , K, AuthorMcMahon, S, AuthorPrise, K, AuthorAloy, MT, AuthorArdail, D, AuthorRodriguez-Lafrasse, C, AuthorPorcel, E, AuthorLacombe, S, AuthorBerbeco, R, AuthorAllouch , A, AuthorPerfettini, JL, AuthorChargari , C, AuthorDeutsch, E, AuthorLe Duc, G, AuthorTillement, O, Author more..
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.

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 Dates: 2018-092019-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1259/bjr.20180365
 Degree: -

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Title: British Journal of Radiology
  Other : Br. J. Radiol.
Source Genre: Journal
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Publ. Info: London : British Institute of Radiology
Pages: - Volume / Issue: 92 (1093) Sequence Number: 20180365 Start / End Page: 1 - 19 Identifier: ISSN: 0007-1285
CoNE: /journals/resource/954927708214