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  Hypothalamus enlargement in mood disorders

Schindler, S., Schmidt, L., Stroske, M., Storch, M., Anwander, A., Trampel, R., et al. (2019). Hypothalamus enlargement in mood disorders. Acta Psychiatrica Scandinavica, 139(1), 56-67. doi:10.1111/acps.12958.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-4E50-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8862-5
Genre: Journal Article

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 Creators:
Schindler, Stephanie1, 2, Author              
Schmidt, Laura2, Author
Stroske, Marie2, Author
Storch, Melanie2, Author
Anwander, Alfred3, Author              
Trampel, Robert1, Author              
Strauß, Maria2, Author
Hegerl, Ulrich2, Author
Geyer, Stefan1, Author              
Schönknecht, Peter4, 5, Author
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
2Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4Out‐patient Department for Sexual‐therapeutic Prevention and Forensic Psychiatry, Leipzig, Germany, ou_persistent22              
5Academic State Hospital Arnsdorf, Germany, ou_persistent22              

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Free keywords: Human; Hypothalamus; Volume; Mood disorders; Magnetic resonance imaging
 Abstract: Objective The purpose of this study was to determine, in vivo, whether the hypothalamus volume is reduced in patients with mood disorders. Methods The cross‐sectional study included 20 unmedicated (MDDu) and 20 medicated patients with major depressive disorder, 21 patients with bipolar disorder, and 23 controls. Twenty of the controls were matched to the MDDu. Seven Tesla, T1‐weighted magnetic resonance images were acquired and processed using methods specifically developed for high‐precision volumetry of the hypothalamus. Results An overall group difference was observed for the left hypothalamus volume corrected for intracranial volume. Planned contrasts identified that the left hypothalamus was approximately 5% larger in each patient group compared with the control group. A paired t‐test with the 20 matched pairs of MDDu and controls and without correction for covariates confirmed the larger left hypothalamus volume in MDDu. Conclusions Contrary to our expectations, the hypothalamus volume was increased in patients with uni‐ and bipolar affective disorders. The effect was left‐sided and independent of medication status or statistical correction for covariates. Supported by emerging evidence that the stress response may be related to structural and functional asymmetry in the brain, our finding suggests a crucial role of the hypothalamus in mood disorders.

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Language(s): eng - English
 Dates: 2018-08-152018-09-192019-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/acps.12958
PMID: 30229855
Other: Epub 2018
 Degree: -

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Title: Acta Psychiatrica Scandinavica
  Other : Acta Psychiatr. Scand.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Copenhagen : Munksgaard.
Pages: - Volume / Issue: 139 (1) Sequence Number: - Start / End Page: 56 - 67 Identifier: ISSN: 0001-690X
CoNE: https://pure.mpg.de/cone/journals/resource/954927587269