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  The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions

Juras, V., Schreiner, M., Laurent, D., Zbýň, Š., Mlynarik, V., Szomolanyi, P., et al. (2019). The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions. Magnetic Resonance Imaging, 55, 86-92. doi:10.1016/j.mri.2018.09.021.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-445A-D Version Permalink: http://hdl.handle.net/21.11116/0000-0002-4591-C
Genre: Journal Article

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Juras, V, Author
Schreiner, M, Author
Laurent, D, Author
Zbýň, Š, Author
Mlynarik, V, Author
Szomolanyi , P, Author
Hager, B, Author
Scotti, C, Author
Goldhahn, J, Author
Heule, R1, 2, Author              
Bieri, O, Author
Trattnig, S, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Objective To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points. Results A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of −5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of −6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T. Conclusion The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.

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 Dates: 2018-092019-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.mri.2018.09.021
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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 55 Sequence Number: - Start / End Page: 86 - 92 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026