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  High-Resolution Axonal Bundle (Fascicle) Assessment and Triple-Echo Steady-State T2 Mapping of the Median Nerve at 7 T: Preliminary Experience

Riegler, G., Drlicek, G., Kronnerwetter, C., Heule, R., Bieri, O., Bodner, G., et al. (2016). High-Resolution Axonal Bundle (Fascicle) Assessment and Triple-Echo Steady-State T2 Mapping of the Median Nerve at 7 T: Preliminary Experience. Investigative Radiology, 51(8), 529-535. doi:10.1097/RLI.0000000000000265.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-448D-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-448E-2
Genre: Journal Article

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Riegler, G, Author
Drlicek, G, Author
Kronnerwetter, C, Author
Heule, R1, Author              
Bieri, O, Author
Bodner, G, Author
Lieba-Samal, D, Author
Trattnig, S, Author
Affiliations:
1University of Basel Hospital, ou_persistent22              

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 Abstract: Objectives: The aims of this preliminary study were to determine the number of axonal bundles (fascicles) in the median nerve, using a high-resolution, proton density (PD)-turbo spin echo (TSE) fat suppression sequence, and to determine normative T2 values, measured by triple-echo steady state, of the median nerve in healthy volunteers and in patients with idiopathic carpal tunnel syndrome (CTS), at 7 T. Materials and methods: This prospective study was approved by the local ethics committee and conducted between March 2014 and January 2015. All study participants gave written informed consent. Six healthy volunteers (30 ± 12 years) and 5 patients with CTS (44 ± 16 years) were included. Measurements were performed on both wrists in all volunteers and on the affected wrist in patients (3 right, 2 left). Based on 5-point scales, 2 readers assessed image quality (1, very poor; 5, very good) and the presence of artifacts that might have a possible influence on fascicle determination (1, severe artifacts; 5, no artifacts) and counted the number of fascicles independently on the PD-TSE sequences. Furthermore, T2 values by region of interest analysis were assessed. Student t tests, a hierarchic linear model, and intraclass correlation coefficients (ICCs) were used for statistical analysis. Results: Proton density-TSE image quality and artifacts revealed a median of 5 in healthy volunteers and 4 in patients with CTS for both readers. Fascicle count of the median nerve ranged from 13 to 23 in all subjects, with an ICC of 0.87 (95% confidence interval [CI], 0.67-0.95). T2 values were significantly higher (P = 0.023) in patients (24.27 ± 0.97 milliseconds [95% CI, 22.19-26.38]) compared with healthy volunteers (21.01 ± 0.65 milliseconds [95% CI, 19.61-22.41]). The ICC for all T2 values was 0.97 (95% CI, 0.96-0.98). Conclusions: This study shows the possibility of fascicle determination of the median nerve in healthy volunteers and patients with CTS (although probably less accurately) with high-resolution 7 T magnetic resonance imaging, as well as significantly higher T2 values in patients with CTS, which seems to be associated with pathophysiological nerve changes. High-Resolution Axonal Bundle (Fascicle) Assessment and Triple-Echo Steady-State T2 Mapping of the Median Nerve at 7 T.

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 Dates: 2016-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1097/RLI.0000000000000265
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Title: Investigative Radiology
  Other : Invest. Radiol.
Source Genre: Journal
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Publ. Info: Philadelphia : J.B. Lippincott.
Pages: - Volume / Issue: 51 (8) Sequence Number: - Start / End Page: 529 - 535 Identifier: ISSN: 0020-9996
CoNE: https://pure.mpg.de/cone/journals/resource/954925408761