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  Tobacco mosaic virus: application of the method of isomorphous replacement to the determination of the helical parameters and radial density distribution

Franklin, R. E., & Holmes, K. C. (1958). Tobacco mosaic virus: application of the method of isomorphous replacement to the determination of the helical parameters and radial density distribution. Acta Crystallographica A, 11(3), 213-220. doi:10.1107/S0365110X58000529.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-4675-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-4676-B
Genre: Journal Article

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Franklin, Rosalind E., Author
Holmes, Kenneth C.1, 2, 3, Author              
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497712              
2Muscle Research, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497731              
3Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497735              

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 Abstract: It is known that in tobacco mosaic virus (TMV) structurally equivalent protein sub-units lie in helical array about the long axis of the rod-shaped particle. It has not, however, proved possible to make a reliable determination of the helical parameters by the usual methods of direct measurement on X-ray fibre diagrams. A quantitative comparison has now been made of the equatorial intensities in fibre diagrams of TMV and of a mercury-substituted TMV, TMV-Hg. This has led to the determination, first of the radial distance of the substituted mercury from the particle axis in TMV-Hg, and then of the parameters of the helical arrangement of protein sub-units in TMV. It also made possible the calculation of the radial density distribution in TMV, the result obtained being in good agreement with the earlier work of Caspar. From a knowledge of the helical parameters and other physical and chemical data it can be shown that the symmetry of TMV is that of the simplest possible helical line group, there being no symmetry elements other than the helical axis.

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Language(s): eng - English
 Dates: 1957-08-081958-03-01
 Publication Status: Published in print
 Pages: 10
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1107/S0365110X58000529
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Title: Acta Crystallographica A
Source Genre: Journal
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Publ. Info: Oxford, England : Blackwell Publishing on behalf of the International Union of Crystallography
Pages: - Volume / Issue: 11 (3) Sequence Number: - Start / End Page: 213 - 220 Identifier: ISSN: 0108-7673
CoNE: https://pure.mpg.de/cone/journals/resource/954927679544