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  Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Krause-Kyora, B., Nutsua, M., Boehme, L., Pierini, F., Pedersen, D. D., Kornell, S.-C., et al. (2018). Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans. Nature Communications, 9: 1569. doi:10.1038/s41467-018-03857-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-4C9B-B Version Permalink: http://hdl.handle.net/21.11116/0000-0002-4C9C-A
Genre: Journal Article

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 Creators:
Krause-Kyora, Ben1, Author              
Nutsua, Marcel, Author
Boehme, Lisa, Author
Pierini, Federica2, Author              
Pedersen, Dorthe Dangvard, Author
Kornell, Sabin-Christin, Author
Drichel, Dmitriy, Author
Bonazzi, Marion, Author
Möbus, Lena, Author
Tarp, Peter, Author
Susat, Julian, Author
Bosse, Esther, Author
Willburger, Beatrix, Author
Schmidt, Alexander H., Author
Sauter, Jürgen, Author
Franke, Andre, Author
Wittig, Michael, Author
Caliebe, Amke, Author
Nothnagel, Michael, Author
Schreiber, Stefan, Author
Boldsen, Jesper L., AuthorLenz, Tobias L.2, Author              Nebel, Almut, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2Emmy Noether Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              

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 Abstract: Leprosy, a chronic infectious disease caused by Mycobacterium leprae (M. leprae), was very common in Europe till the 16th century. Here, we perform an ancient DNA study on medieval skeletons from Denmark that show lesions specific for lepromatous leprosy (LL). First, we test the remains for M. leprae DNA to confirm the infection status of the individuals and to assess the bacterial diversity. We assemble 10 complete M. leprae genomes that all differ from each other. Second, we evaluate whether the human leukocyte antigen allele DRB1*15:01, a strong LL susceptibility factor in modern populations, also predisposed medieval Europeans to the disease. The comparison of genotype data from 69 M. leprae DNA-positive LL cases with those from contemporary and medieval controls reveals a statistically significant association in both instances. In addition, we observe that DRB1*15:01 co-occurs with DQB1*06:02 on a haplotype that is a strong risk factor for inflammatory diseases today.

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Language(s): eng - English
 Dates: 2017-07-142018-03-162018-05-01
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: Other: shh991
DOI: 10.1038/s41467-018-03857-x
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 1569 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723