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  White matter network alterations in patients with depersonalization/derealization disorder

Sierk, A., Daniels, J. K., Manthey, A., Kok, J. G., Leemans, A., Gaebler, M., et al. (2018). White matter network alterations in patients with depersonalization/derealization disorder. Journal of Psychiatry & Neuroscience, 43(4): 170110. doi:10.1503/jpn.170110.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-50F4-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-0010-A
Genre: Journal Article

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 Creators:
Sierk, Anika 1, Author
Daniels, Judith K. 1, Author
Manthey, Antje 1, Author
Kok, Jelmer G. 1, Author
Leemans, Alexander 1, Author
Gaebler, Michael2, Author              
Lamke, Jan-Peter 1, Author
Kruschwitz, Johann 1, Author
Walter, Henrik 1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Background: Depersonalization/derealization disorder (DPD) is a chronic and distressing condition characterized by detachment from oneself and/or the external world. Neuroimaging studies have associated DPD with structural and functional alterations in a variety of distinct brain regions. Such local neuronal changes might be mediated by altered interregional white matter connections. However, to our knowledge, no research on network characteristics in this patient population exists to date. Methods: We explored the structural connectome in 23 individuals with DPD and 23 matched, healthy controls by applying graph theory to diffusion tensor imaging data. Mean interregional fractional anisotropy (FA) was used to define the network weights. Group differences were assessed using network-based statistics and a link-based controlling procedure. Results: Our main finding refers to lower FA values within left temporal and right temporoparietal regions in individuals with DPD than in healthy controls when using a link-based controlling procedure. These links were also associated with dissociative symptom severity and could not be explained by anxiety or depression scores. Using network-based statistics, no significant results emerged. However, we found a trend for 1 subnetwork that may support the model of frontolimbic dysbalance suggested to underlie DPD symptomatology. Limitations: To ensure ecological validity, patients with certain comorbidities or psychotropic medication were included in the study. Confirmatory replications are necessary to corroborate the results of this explorative investigation. Conclusion: In patients with DPD, the structural connectivity between brain regions crucial for multimodal integration and emotion regulation may be altered. Aberrations in fibre tract communication seem to be not solely a secondary effect of local grey matter volume loss, but may present a primary pathophysiology in patients with DPD.

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Language(s): eng - English
 Dates: 2017-12-012017-06-072018-01-212018-06-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1503/jpn.170110
PMID: 29877178
Other: Epub ahead of print
 Degree: -

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Title: Journal of Psychiatry & Neuroscience
  Abbreviation : J Psychiatry Neurosci
Source Genre: Journal
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Publ. Info: Ottawa, Ont., Canada : Journal of Psychiatry and Neuroscience
Pages: - Volume / Issue: 43 (4) Sequence Number: 170110 Start / End Page: - Identifier: ISSN: 1180-4882
CoNE: https://pure.mpg.de/cone/journals/resource/1180-4882