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  Influence of the extracellular matrix on water mobility in subcortical gray matter

Georgi, J., Metere, R., Jäger, C., Morawski, M., & Möller, H. E. (2019). Influence of the extracellular matrix on water mobility in subcortical gray matter. Magnetic Resonance in Medicine, 81(2), 1265-1279. doi:10.1002/mrm.27459.

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Georgi, Jakob1, Autor           
Metere, Riccardo1, Autor           
Jäger, Carsten2, 3, Autor           
Morawski, Markus 3, Autor
Möller, Harald E.1, 4, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: Diffusion; Extracellular matrix; Spin–lattice relaxation; Spin–spin relaxation; Water compartments
 Zusammenfassung: Purpose Water mobility in tissues is related to the microstructure that modulates diffusion and spin relaxation. Previous work has shown that the extracellular matrix (ECM) impacts water diffusion in cartilage. To investigate if similar contributions to image contrast exist for brain, which is characterized by a substantially lower ECM content, diffusion and relaxation were studied in fixed samples from goat and human thalamus before and after enzymatic digestion of ECM compounds. Selected experiments in human corpus callosum were included for comparing subcortical gray matter and white matter. Methods Digestion of matrix components was achieved by treatment with hyaluronidase. Nonlocalized pulsed field gradient measurements were performed with values between 0.6 and 18,000 s/mm² at 3T and temperatures between 0°C and 20°C, in addition to T1 and T2 relaxation measurements. The data were fitted to multiexponential models to account for different water compartments. After the measurements, the samples were sliced and stained for ECM‐sensitive markers to verify efficient digestion. Results Microstructural alterations associated with hyaluronan digestion did not lead to measurable effects on water diffusion or . However, T1 of the main relaxographic component, attributed to intra‐/extracellular water, decreased by 7%. Conclusion Investigations with very strong gradients did not reveal a detectable effect on water diffusion or after hyaluronan removal, indicating that the brain ECM content is too low to produce a detectable effect. The subtle alteration of T1 upon hyaluronidase treatment might reflect a modulation of intercompartmental water exchange properties.

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Sprache(n): eng - English
 Datum: 2018-06-122018-05-022018-06-292018-09-142019-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/mrm.27459
PMID: 30276849
Anderer: Epub 2018
 Art des Abschluß: -

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Projektname : -
Grant ID : HA‐314
Förderprogramm : -
Förderorganisation : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”
Projektname : Ultra-High Field Magnetic Resonance Imaging / HIMR
Grant ID : 316716
Förderprogramm : Funding Programme 7 (FP7-PEOPLE-2012-ITN)
Förderorganisation : European Commission (EC)
Projektname : Ultrafast and temporally precise information processing: Normal and dysfunctional hearing / SPP 1608
Grant ID : MO2249/2‐1
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
Projektname : Computational Connectomics / SPP 2041
Grant ID : MO2249/3‐1
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Free State of Saxony

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Titel: Magnetic Resonance in Medicine
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 81 (2) Artikelnummer: - Start- / Endseite: 1265 - 1279 Identifikator: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149