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  Distinct modes of functional connectivity induced by movie-watching

Demirtas, M., Ponce-Alvarez, A., Gilson, M., Hagmann, P., Mantini, D., Betti, V., et al. (2019). Distinct modes of functional connectivity induced by movie-watching. NeuroImage, 184, 335-348. doi:10.1016/j.neuroimage.2018.09.042.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-4F28-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-928C-A
Genre: Journal Article

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 Creators:
Demirtas, Murat1, 2, Author
Ponce-Alvarez, Adrian2, Author
Gilson, Matthieu2, Author
Hagmann, Patric3, Author
Mantini, Dante4, 5, Author
Betti, Viviana 6, 7, Author
Romani, Gian Luca8, Author
Friston, Karl9, Author
Corbetta, Maurizio10, 11, Author
Deco, Gustavo2, 12, 13, 14, Author              
Affiliations:
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA, ou_persistent22              
2Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department of Radiology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Research Center for Motor Control and Neuroplasticity, Katholieke Universiteit Leuven, Belgium, ou_persistent22              
5Neuroimaging Laboratory, IRCCS: Scientific Institute for Research and Healthcare, Rome, Italy, ou_persistent22              
6Department of Psychology, Sapienza University of Rome, Italy, ou_persistent22              
7Foundation Saint Lucia, Rome, Italy, ou_persistent22              
8Institute of Advanced Biomedical Technologies (ITAB), Gabriele D'Annunzio University, Chieti-Pescara, Italy, ou_persistent22              
9Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
10Padova Neuroscience Center (PNC), University of Padova, Italy, ou_persistent22              
11Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA, ou_persistent22              
12Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
13Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
14School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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 Abstract: A fundamental question in systems neuroscience is how endogenous neuronal activity self-organizes during particular brain states. Recent neuroimaging studies have demonstrated systematic relationships between resting-state and task-induced functional connectivity (FC). In particular, continuous task studies, such as movie watching, speak to alterations in coupling among cortical regions and enhanced fluctuations in FC compared to the resting-state. This suggests that FC may reflect systematic and large-scale reorganization of functionally integrated responses while subjects are watching movies. In this study, we characterized fluctuations in FC during resting-state and movie-watching conditions. We found that the FC patterns induced systematically by movie-watching can be explained with a single principal component. These condition-specific FC fluctuations overlapped with inter-subject synchronization patterns in occipital and temporal brain regions. However, unlike inter-subject synchronization, condition-specific FC patterns were characterized by increased correlations within frontal brain regions and reduced correlations between frontal-parietal brain regions. We investigated these condition-specific functional variations as a shorter time scale, using time-resolved FC. The time-resolved FC showed condition-specificity over time; notably when subjects watched both the same and different movies. To explain self-organisation of global FC through the alterations in local dynamics, we used a large-scale computational model. We found that condition-specific reorganization of FC could be explained by local changes that engendered changes in FC among higher-order association regions, mainly in frontal and parietal cortices.

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Language(s): eng - English
 Dates: 2018-09-012018-06-142018-09-162018-09-172019-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.09.042
PMID: 30237036
PMC: PMC6248881
Other: Epub 2018
 Degree: -

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Project name : Human Brain Project Specific Grant Agreement 2 / HBP SGA2
Grant ID : 785907
Funding program : Horizon 2020
Funding organization : European Union (EU)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : -
Grant ID : 5R01NS095741
Funding program : -
Funding organization : National Institutes of Health (NIH)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 184 Sequence Number: - Start / End Page: 335 - 348 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166