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  Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson’s disease patients

Ballarini, T., Růžička, F., Bezdicek, O., Růžička, E., Roth, J., Villringer, A., et al. (2018). Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson’s disease patients. Scientific Reports, 8: 14328. doi:10.1038/s41598-018-31988-0.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-50E3-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A377-F
Genre: Journal Article

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 Creators:
Ballarini, Tommaso1, Author              
Růžička, Filip 2, Author
Bezdicek, Ondrej 2, Author
Růžička, Evžen 2, Author
Roth, Jan 2, Author
Villringer, Arno1, 3, Author              
Vymazal, Josef 4, Author
Mueller, Karsten5, Author              
Schroeter, Matthias L.1, 3, 6, Author              
Jech, Robert 2, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany , ou_persistent22              
4Department of Radiology, Na Homolce Hospital, Prague, Czech Republic, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany , ou_persistent22              

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 Abstract: The effects of dopaminergic therapy for Parkinson’s disease (PD) on the brain functional architecture are still unclear. We investigated this topic in 31 PD patients (disease duration: 11.2 ± (SD) 3.6 years) who underwent clinical and MRI assessments under chronic dopaminergic treatment (duration: 8.3 ± (SD) 4.4 years) and after its withdrawal. Thirty healthy controls were also included. Functional and morphological changes were studied, respectively, with eigenvector centrality mapping and seed-based connectivity, and voxel-based morphometry. Patients off medication, compared to controls, showed increased connectivity in cortical sensorimotor areas extending to the cerebello-thalamo-cortical pathway and parietal and frontal brain structures. Dopaminergic therapy normalized this increased connectivity. Notably, patients showed decreased interconnectedness in the medicated compared to the unmedicated condition, encompassing putamen, precuneus, supplementary motor and sensorimotor areas bilaterally. Similarly, lower connectivity was found comparing medicated patients to controls, overlapping with the within-group comparison in the putamen. Seed-based analyses revealed that dopaminergic therapy reduced connectivity in motor and default mode networks. Lower connectivity in the putamen correlated with longer disease duration, medication dose, and motor symptom improvement. Notably, atrophy and connectivity changes were topographically dissociated. After chronic treatment, dopaminergic therapy decreases connectivity of key motor and default mode network structures that are abnormally elevated in PD off condition.

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Language(s): eng - English
 Dates: 2018-04-232018-08-302018-09-25
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-018-31988-0
PMID: 30254336
PMC: PMC6156510
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Project name : -
Grant ID : 16–13323 S
Funding program : -
Funding organization : Czech Science Foundation GAČR
Project name : -
Grant ID : -
Funding program : Progres Q27/LF1
Funding organization : Charles University
Project name : -
Grant ID : SCHR 774/5-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : 11362
Funding program : -
Funding organization : Michael J. Fox Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

Source 1

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 14328 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322