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  Megahertz serial crystallography

Wiedorn, M. O., Oberthür, D., Bean, R., Schubert, R., Werner, N., Abbey, B., et al. (2018). Megahertz serial crystallography. Nature Communications, 9: 4025, pp. 1-11. doi:10.1038/s41467-018-06156-7.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-521C-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-521D-2
Genre: Journal Article

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Wiedorn, Max O., Author
Oberthür, Dominik, Author
Bean, Richard, Author
Schubert, Robin, Author
Werner, Nadine, Author
Abbey, Brian, Author
Aepfelbacher, Martin, Author
Adriano, Luigi, Author
Allahgholi, Aschkan, Author
Al-Qudami, Nasser, Author
Andreasson, Jakob, Author
Aplin, Steve, Author
Awel, Salah, Author
Ayyer, Kartik, Author
Bajt, Saša, Author
Barák, Imrich, Author
Bari, Sadia, Author
Bielecki, Johan, Author
Botha, Sabine, Author
Boukhelef, Djelloul, Author
Brehm, Wolfgang, AuthorBrockhauser, Sandor, AuthorCheviakov, Igor, AuthorColeman, Matthew A., AuthorCruz-Mazo, Francisco, AuthorDanilevski, Cyril, AuthorDarmanin, Connie, AuthorDoak, R. Bruce1, Author              Domaracky, Martin, AuthorDörner, Katerina, AuthorDu, Yang, AuthorFangohr, Hans, AuthorFleckenstein, Holger, AuthorFrank, Matthias, AuthorFromme, Petra, AuthorGañán-Calvo, Alfonso M., AuthorGevorkov, Yaroslav, AuthorGiewekemeyer, Klaus, AuthorGinn, Helen Mary, AuthorGraafsma, Heinz, AuthorGraceffa, Rita, AuthorGreiffenberg, Dominic, AuthorGumprecht, Lars, AuthorGöttlicher, Peter, AuthorHajdu, Janos, AuthorHauf, Steffen, AuthorHeymann, Michael, AuthorHolmes, Susannah, AuthorHorke, Daniel A., AuthorHunter, Mark S., AuthorImlau, Siegfried, AuthorKaukher, Alexander, AuthorKim, Yoonhee, AuthorKlyuev, Alexander, AuthorKnoška, Juraj, AuthorKobe, Bostjan, AuthorKuhn, Manuela, AuthorKupitz, Christopher, AuthorKüpper, Jochen, AuthorLahey-Rudolph, Janine Mia, AuthorLaurus, Torsten, AuthorLe Cong, Karoline, AuthorLetrun, Romain, AuthorXavier, P. Lourdu, AuthorMaia, Luis, AuthorMaia, Filipe R. N. C., AuthorMariani, Valerio, AuthorMesserschmidt, Marc, AuthorMetz, Markus, AuthorMezza, Davide, AuthorMichelat, Thomas, AuthorMills, Grant, AuthorMonteiro, Diana C. F., AuthorMorgan, Andrew, AuthorMühlig, Kerstin, AuthorMunke, Anna, AuthorMünnich, Astrid, AuthorNette, Julia, AuthorNugent, Keith A., AuthorNuguid, Theresa, AuthorOrville, Allen M., AuthorPandey, Suraj, AuthorPena, Gisel, AuthorVillanueva-Perez, Pablo, AuthorPoehlsen, Jennifer, AuthorPrevitali, Gianpietro, AuthorRedecke, Lars, AuthorRiekehr, Winnie Maria, AuthorRohde, Holger, AuthorRound, Adam, AuthorSafenreiter, Tatiana, AuthorSarrou, Iosifina, AuthorSato, Tokushi, AuthorSchmidt, Marius, AuthorSchmitt, Bernd, AuthorSchönherr, Robert, AuthorSchulz, Joachim, AuthorSellberg, Jonas A., AuthorSeibert, M. Marvin, AuthorSeuring, Carolin, AuthorShelby, Megan L., AuthorShoeman, Robert L.1, Author              Sikorski, Marcin, AuthorSilenzi, Alessandro, AuthorStan, Claudiu A., AuthorShi, Xintian, AuthorStern, Stephan, AuthorSztuk-Dambietz, Jola, AuthorSzuba, Janusz, AuthorTolstikova, Aleksandra, AuthorTrebbin, Martin, AuthorTrunk, Ulrich, AuthorVagovic, Patrik, AuthorVe, Thomas, AuthorWeinhausen, Britta, AuthorWhite, Thomas A., AuthorWrona, Krzysztof, AuthorXu, Chen, AuthorYefanov, Oleksandr, AuthorZatsepin, Nadia, AuthorZhang, Jiaguo, AuthorPerbandt, Markus, AuthorMancuso, Adrian P., AuthorBetzel, Christian, AuthorChapman, Henry, AuthorBarty, Anton, Author more..
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.

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Language(s): eng - English
 Dates: 2018-08-052018-08-212018-10-02
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-018-06156-7
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 4025 Start / End Page: 1 - 11 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723