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  Cannabinoid Receptor Type 1 in the Brain Regulates the Affective Component of Visceral Pain in Mice

Bajic, D., Monory, K., Conrad, A., Maul, C., Schmid, R. M., Wotjak, C. T., et al. (2018). Cannabinoid Receptor Type 1 in the Brain Regulates the Affective Component of Visceral Pain in Mice. NEUROSCIENCE, 384, 397-405. doi:10.1016/j.neuroscience.2018.05.041.

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 Creators:
Bajic, Danica1, Author
Monory, Krisztina1, Author
Conrad, Andrea1, Author
Maul, Christina1, Author
Schmid, Roland M.1, Author
Wotjak, Carsten T.2, Author           
Stein-Thoeringer, Christoph K.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              

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Free keywords: ACID AMIDE HYDROLASE; ENDOCANNABINOID SYSTEM; NEUROPATHIC-PAIN; PREFRONTAL CORTEX; ABDOMINAL-PAIN; CB1; BEHAVIOR; TRPV1; MODULATION; CHANNELSNeurosciences & Neurology; visceral pain; cannabinoid receptor type 1; brain; affective; pancreatitis;
 Abstract: Endocannabinoids acting through cannabinoid receptor type 1 (CB1) are major modulators of peripheral somatic and visceral nociception. Although only partially studied, some evidence suggests a particular role of CB1 within the brain in nociceptive processes. As the endocannabinoid system regulates affect and emotional behaviors, we hypothesized that cerebral CB1 influences affective processing of visceral pain-related behaviors in laboratory animals. To study nocifensive responses modulated by supraspinal CB1, we used conditional knock-out mice lacking CB1 either in cortical glutamatergic neurons (Glu-CBI-KO), or in forebrain GABAergic neurons (GABA-CBI-KO), or in principal neurons of the forebrain (CaMK-CBI-KO). These mutant mice and mice treated with the CB1 antagonist SR141716 were tested for different pain-related behaviors. In an acetic acid-induced abdominal constriction test, supraspinal CB1 deletions did not affect nocifensive responses. In the cerulein-model of acute pancreatitis, mechanical allodynia or hyperalgesia were not changed, but Glu-CB1- and CaMK-CBI-KO mice showed significantly increased facial grimacing scores indicating increased affective responses to this noxious visceral stimulus. Similarly, these brain-specific CB1 KO mice also showed significantly changed thermal nociception in a hot-plate test. These results reveal a novel, and important role of CB1 expressed by cortical glutamatergic neurons in the affective component of visceral nociception. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Title: NEUROSCIENCE
Source Genre: Journal
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Publ. Info: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND : PERGAMON-ELSEVIER SCIENCE LTD
Pages: - Volume / Issue: 384 Sequence Number: - Start / End Page: 397 - 405 Identifier: ISSN: 0306-4522