非表示:
キーワード:
CORTICAL MIDLINE STRUCTURES; POSTERIOR CINGULATE CORTEX; JOINT
ATTENTION; MEMORY RETRIEVAL; DEFAULT-MODE; SCHIZOPHRENIA; DEPRESSION;
COGNITION; AUTISM; BRAINNeurosciences & Neurology; eye-tracking; hallucinogens; joint attention; psychedelics; serotonin;
social cognition;
要旨:
Distortions of self-experience are critical symptoms of psychiatric disorders and have detrimental effects on social interactions. In light of the immense need for improved and targeted interventions for social impairments, it is important to better understand the neurochemical substrates of social interaction abilities. We therefore investigated the pharmacological and neural correlates of self-and other-initiated social interaction. In a double-blind, randomized, counterbalanced, crossover study 24 healthy human participants (18 males and 6 females) received either (1) placebo + placebo, (2) placebo + lysergic acid diethylamide (LSD; 100 mu g, p.o.), or (3) ketanserin (40 mg, p.o.) + LSD (100 mu g, p.o.) on three different occasions. Participants took part in an interactive task using eye-tracking and functional magnetic resonance imaging completing trials of self-and other-initiated joint and non-joint attention. Results demonstrate first, that LSD reduced activity in brain areas important for self-processing, but also social cognition; second, that change in brain activity was linked to subjective experience; and third, that LSD decreased the efficiency of establishing joint attention. Furthermore, LSD-induced effects were blocked by the serotonin 2A receptor (5-HT2AR) antagonist ketanserin, indicating that effects of LSD are attributable to 5-HT2AR stimulation. The current results demonstrate that activity in areas of the "social brain" can be modulated via the 5-HT2AR thereby pointing toward this system as a potential target for the treatment of social impairments associated with psychiatric disorders.
