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Free keywords:
ACUTE CORONARY SYNDROME; D PERSONALITY; PSYCHOMETRIC PROPERTIES;
DEPRESSION; CHILDREN; RELIABILITY; DISORDERS; DS14; VALIDITYScience & Technology - Other Topics; Fluoxetine; Adolescent; Treatment response; Ex post-facto study; Type D
personality; Personality; Treatment response; SSRI;
Abstract:
Background. Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study. used psychological and biological markers for (retrospective) prediction of treatment response to fluoxetine in depressed and/or anxious adolescents.
Methods. Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNF alpha, IL-6, and IL-lb were measured pre- and post-treatment.
Results. There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFa levels as well as Type D personality to non-response.
Conclusions. In this exploratory study, the most significant contributor to non response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personalityy in psychiatric setting may contribute to the understanding of treatment response and have clinical utility.
