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  An integrated lab-on-a-chip approach to study heterogeneous enantioselective catalysts at the microscale

Warias, R., Zaghi, A., Heiland, J. J., Piendl, S. K., Gilmore, K., Seeberger, P. H., et al. (2018). An integrated lab-on-a-chip approach to study heterogeneous enantioselective catalysts at the microscale. ChemCatChem, 10(23), 5382-5385. doi:10.1002/cctc.201801637.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-6864-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-57CD-2
Genre: Journal Article

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 Creators:
Warias, Rico, Author
Zaghi, Anna, Author
Heiland, Josef J., Author
Piendl, Sebastian K., Author
Gilmore, Kerry1, Author              
Seeberger, Peter H.2, Author              
Massi, Alessandro, Author
Belder, Detlev, Author
Affiliations:
1Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: lab-on-a-chip, Flow Chemistry, heterogeneous catalysis, supported enantioselective catalysts
 Abstract: An integrated lab-on-a-chip enables the rapid analysis of heterogenized enantioselective organocatalysis at the microscale. A packed-bed microreactor was seamlessly integrated with a downstream chiral high pressure liquid chromatography (HPLC) functionality to study enantioselective transformations on a single microfluidic glass chip. Hyphenation to mass spectrometry allows for the rapid investigation of the selectivity and the substrate scope of microgram amounts of catalyst beads. Optimization of reaction conditions is possible with minimal reagent consumption and instant analytical feedback.

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Language(s): eng - English
 Dates: 2018-10-112018
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/cctc.201801637
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Title: ChemCatChem
  Other : ChemCatChem
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 10 (23) Sequence Number: - Start / End Page: 5382 - 5385 Identifier: ISSN: 1867-3880