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  Selective advantages favour high genomic AT-contents in intracellular elements

Dietel, A.-K., Merker, H., Kaltenpoth, M., & Kost, C. (2019). Selective advantages favour high genomic AT-contents in intracellular elements. PLoS Genetics, 15(4): e1007778. doi:10.1371/journal.pgen.1007778.

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http://dx.doi.org/10.1371/journal.pgen.1007778 (Publisher version)
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 Creators:
Dietel, Anne-Kathrin1, 2, Author              
Merker, Holger2, Author              
Kaltenpoth, Martin3, Author              
Kost, Christian2, Author              
Affiliations:
1IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society, Jena, DE, ou_421900              
2Research Group Dr. C. Kost, Experimental Ecology and Evolution, Department of Bioorganic Chemistry, Prof. Dr. W. Boland, MPI for Chemical Ecology, Max Planck Society, ou_421906              
3External Organizations, ou_persistent22              

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 Abstract: Extrachromosomal genetic elements generally exhibit increased AT-contents relative to their hosts’ DNA. The AT-bias of endosymbiotic genomes is commonly explained by neutral evolutionary processes. Here we show experimentally that an increased AT-content of host-dependent elements can be selectively favoured on the host level. Manipulating the nucleotide composition of bacterial cells by introducing A+T- or G+C-rich plasmids, we demonstrate that cells containing GC-rich plasmids are less fit than cells containing AT-rich plasmids. Moreover, the cost of GC-rich elements could be compensated by providing G+C-, but not A+T-precursors, thus linking the observed fitness effects to the cytoplasmic availability of nucleotides. Our work identifies selection as a strong evolutionary force that drives the genomes of intracellular genetic elements toward higher A+T contents.

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 Dates: 2018-102019-04-29
 Publication Status: Published online
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 Identifiers: Other: KOS025
DOI: 10.1371/journal.pgen.1007778
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Title: PLoS Genetics
  Other : PLoS Genet.
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 15 (4) Sequence Number: e1007778 Start / End Page: - Identifier: ISSN: 1553-7390
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180