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  Disruption of neurite morphology parallels MS progression

Spanò, B., Giuletti, G., Pisani, V., Morreale, M., Tuzzi, E., Nocentini, U., et al. (2018). Disruption of neurite morphology parallels MS progression. Neurology: Neuroimmunology & Neuroinflammation, 5(6), 1-11. doi:10.1212/NXI.0000000000000502.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-62D9-B Version Permalink: http://hdl.handle.net/21.11116/0000-0002-62DA-A
Genre: Journal Article

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 Creators:
Spanò, B, Author
Giuletti, G, Author
Pisani, V, Author
Morreale, M, Author
Tuzzi, E1, 2, Author              
Nocentini, U, Author
Francia, A, Author
Caltagirone, C, Author
Bozzali, M, Author
Cercignani, M, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Objectives: To apply advanced diffusion MRI methods to the study of normal-appearing brain tissue in MS and examine their correlation with measures of clinical disability. Methods: A multi-compartment model of diffusion MRI called neurite orientation dispersion and density imaging (NODDI) was used to study 20 patients with relapsing-remitting MS (RRMS), 15 with secondary progressive MS (SPMS), and 20 healthy controls. Maps of NODDI were analyzed voxel-wise to assess the presence of abnormalities within the normal-appearing brain tissue and the association with disease severity. Standard diffusion tensor imaging (DTI) parameters were also computed for comparing the 2 techniques. Results: Patients with MS showed reduced neurite density index (NDI) and increased orientation dispersion index (ODI) compared with controls in several brain areas (p < 0.05), with patients with SPMS having more widespread abnormalities. DTI indices were also sensitive to some changes. In addition, patients with SPMS showed reduced ODI in the thalamus and caudate nucleus. These abnormalities were associated with scores of disease severity (p < 0.05). The association with the MS functional composite score was higher in patients with SPMS compared with patients with RRMS. Conclusions: NODDI and DTI findings are largely overlapping. Nevertheless, NODDI helps interpret previous findings of increased anisotropy in the thalamus of patients with MS and are consistent with the degeneration of selective axon populations.

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 Dates: 2018-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1212/NXI.0000000000000502
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Title: Neurology: Neuroimmunology & Neuroinflammation
Source Genre: Journal
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Pages: - Volume / Issue: 5 (6) Sequence Number: - Start / End Page: 1 - 11 Identifier: eDoc: e502
ISSN: 2332-7812