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  Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

Lenz, T. L., Hafer, N., Samonte, I. E., Yeates, S. E., & Milinski, M. (2018). Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes. Evolution. doi:10.1111/evo.13591.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-673D-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-B597-7
Genre: Journal Article

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Lenz_2018_Evolution.pdf (Publisher version), 578KB
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https://creativecommons.org/licenses/by-nc-nd/4.0/

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 Creators:
Lenz, Tobias L.1, 2, 3, Author              
Hafer, Nina3, Author              
Samonte, Irene E.3, Author              
Yeates, Sarah E.3, Author              
Milinski, Manfred3, 4, Author              
Affiliations:
1Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              
2Emmy Noether Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              
3Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
4Emeritus Group Milinski, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2591693              

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Free keywords: Gasterosteus aculeatus, in vitro fertilization, major histocompatibility complex, MHC divergence, postcopulatory sexual selection, three-spined stickleback
 Abstract: Abstract Females choose specific mates in order to produce fitter offspring. However, several factors interfere with females' control over fertilization of their eggs, including sneaker males and phenotypically unpredictable allele segregation during meiosis. Mate choice at the individual level thus provides only a poor approximation for obtaining the best genetic match. Consequently, postcopulatory sperm selection by female oocytes has been proposed as a mechanism to achieve complementary combinations of parental haplotypes. Here, using controlled in vitro fertilization of three-spined stickleback eggs, we find haplotype-specific fertilization bias toward gametes with complementary major histocompatibility complex (MHC) immunogenes. The resulting zygote (and thus offspring) genotypes exhibit an intermediate level of individual MHC diversity that was previously shown to confer highest pathogen resistance. Our finding of haplotype-specific gamete selection thus represents an intriguing mechanism for fine-tuned optimization of the offspring's immune gene composition and an evolutionary advantage in the Red Queen dynamics of host-parasite coevolution.

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Language(s): eng - English
 Dates: 2018-04-232018-08-132018-09-242018-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/evo.13591
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Project name : Deutsche Forschungsgemeinschaft (DFG)
Grant ID : LE 2593/3-1
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Title: Evolution
  Other : Evolution
Source Genre: Journal
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Publ. Info: Boulder, Colo.? : Society for the Study of Evolution
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0014-3820
CoNE: https://pure.mpg.de/cone/journals/resource/991042730870254

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Title: Evolution
  Alternative Title : Evolution
Source Genre: Journal
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Publ. Info: Wiley/Blackwell (10.1111)
Pages: - Volume / Issue: 72 (11) Sequence Number: - Start / End Page: 2478 - 2490 Identifier: ISBN: 0014-3820