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  Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

Lenz, T. L., Hafer, N., Samonte, I. E., Yeates, S. E., & Milinski, M. (2018). Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes. Evolution, 72(11), 2478-2490. doi:10.1111/evo.13591.

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Lenz_2018_Evolution.pdf (Verlagsversion), 578KB
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 Urheber:
Lenz, Tobias L.1, Autor           
Hafer, Nina2, Autor           
Samonte, Irene E.2, Autor           
Yeates, Sarah E.2, Autor           
Milinski, Manfred3, Autor           
Affiliations:
1Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              
2Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
3Emeritus Group Milinski, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2591693              

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Schlagwörter: Gasterosteus aculeatus, in vitro fertilization, major histocompatibility complex, MHC divergence, postcopulatory sexual selection, three-spined stickleback
 Zusammenfassung: Abstract Females choose specific mates in order to produce fitter offspring. However, several factors interfere with females' control over fertilization of their eggs, including sneaker males and phenotypically unpredictable allele segregation during meiosis. Mate choice at the individual level thus provides only a poor approximation for obtaining the best genetic match. Consequently, postcopulatory sperm selection by female oocytes has been proposed as a mechanism to achieve complementary combinations of parental haplotypes. Here, using controlled in vitro fertilization of three-spined stickleback eggs, we find haplotype-specific fertilization bias toward gametes with complementary major histocompatibility complex (MHC) immunogenes. The resulting zygote (and thus offspring) genotypes exhibit an intermediate level of individual MHC diversity that was previously shown to confer highest pathogen resistance. Our finding of haplotype-specific gamete selection thus represents an intriguing mechanism for fine-tuned optimization of the offspring's immune gene composition and an evolutionary advantage in the Red Queen dynamics of host-parasite coevolution.

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Sprache(n): eng - English
 Datum: 2018-04-232018-08-132018-09-242018-11
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1111/evo.13591
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Projektname : Deutsche Forschungsgemeinschaft (DFG)
Grant ID : LE 2593/3-1
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Titel: Evolution
  Andere : Evolution
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Boulder, Colo.? : Society for the Study of Evolution
Seiten: - Band / Heft: 72 (11) Artikelnummer: - Start- / Endseite: 2478 - 2490 Identifikator: ISSN: 0014-3820
CoNE: https://pure.mpg.de/cone/journals/resource/991042730870254