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  Analytic methods in microbiome studies

Rausch, P., & Künstner, A. (2018). Analytic methods in microbiome studies. In G. Ragab, T. P. Atkinson, & M. L. Stoll (Eds.), The Microbiome in Rheumatic Diseases and Infection (pp. 29-42). Cham: Springer International Publishing. doi:10.1007/978-3-319-79026-8_3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-6759-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-675F-1
Genre: Book Chapter

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Rausch-Künstner2018_Chapter_AnalyticMethodsInMicrobiomeStu.pdf (Publisher version), 553KB
 
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 Creators:
Rausch, Philipp1, Author              
Künstner, Axel1, Author              
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1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: Rheumatoid arthritis; Microbiota; Methods
 Abstract: Most autoimmune diseases are polygenic conditions, with strong environmental components. For example, rheumatoid arthritis (RA) has approximately 100 risk alleles, with small individual effect sizes, indicating interaction of environmental factors with genetic susceptibilities in disease development (Okada et al., Nature 506:376--381, 2014). A theme throughout this textbook is the association of microbial populations with disease development. The last 10 years have witnessed an explosion of technologies and informatics pipelines permitting in-depth exploration of these microbial communities. Thus, it is important to investigate microbial communities in autoimmune diseases like RA in a systematic and comparable way to find common dynamics in the microbiome within and across studies that may lead to diagnostic or therapeutic innovations. The previous chapter reviewed multiple technologies, old and new, to query the microbiota; this chapter will focus on the analysis of commonly used sequencing approaches.

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Language(s): eng - English
 Dates: 2018-08-202018
 Publication Status: Published in print
 Pages: -
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 Identifiers: DOI: 10.1007/978-3-319-79026-8_3
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Title: The Microbiome in Rheumatic Diseases and Infection
Source Genre: Book
 Creator(s):
Ragab, Gaafar, Editor
Atkinson, T. Prescott, Editor
Stoll, Matthew L., Editor
Affiliations:
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Publ. Info: Cham : Springer International Publishing
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 29 - 42 Identifier: ISBN: 978-3-319-79026-8