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  Dealing with the adaptive immune system during de novo evolution of genes from intergenic sequences

Bekpen, C., Xie, C., & Tautz, D. (2018). Dealing with the adaptive immune system during de novo evolution of genes from intergenic sequences. BMC Evolutionary Biology, 18(1), 1-11. doi:10.1186/s12862-018-1232-z.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-67F1-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-67F2-9
Genre: Journal Article

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 Creators:
Bekpen, Cemalettin1, Author              
Xie, Chen1, Author              
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: Transcriptome; de novo genes; Adaptive immune system; Aire; Mouse populations
 Abstract: The adaptive immune system of vertebrates has an extraordinary potential to sense and neutralize foreign antigens entering the body. De novo evolution of genes implies that the genome itself expresses novel antigens from intergenic sequences which could cause a problem with this immune system. Peptides from these novel proteins could be presented by the major histocompatibility complex (MHC) receptors to the cell surface and would be recognized as foreign. The respective cells would then be attacked and destroyed, or would cause inflammatory responses. Hence, de novo expressed peptides have to be introduced to the immune system as being self-peptides to avoid such autoimmune reactions. The regulation of the distinction between self and non-self starts during embryonic development, but continues late into adulthood. It is mostly mediated by specialized cells in the thymus, but can also be conveyed in peripheral tissues, such as the lymph nodes and the spleen. The self-antigens need to be exposed to the reactive T-cells, which requires the expression of the genes in the respective tissues. Since the initial activation of a promotor for new intergenic transcription of a de novo gene could occur in any tissue, we should expect that the evolutionary establishment of a de novo gene in animals with an adaptive immune system should also involve expression in at least one of the tissues that confer self-recognition.

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Language(s): eng - English
 Dates: 2018-01-242018-07-162018-08-032018
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1186/s12862-018-1232-z
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Title: BMC Evolutionary Biology
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: 121 Volume / Issue: 18 (1) Sequence Number: - Start / End Page: 1 - 11 Identifier: ISSN: 1471-2148
CoNE: https://pure.mpg.de/cone/journals/resource/111000136905006